Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376  

作　　者：Xiao-dong Luan Bin-xian Chen Wei-juan Shang Wan-chao Yin Ye Jin Lei-ke Zhang H.Eric Xu Shu-yang Zhang 

机构地区：[1]School of Medicine,Tsinghua University,Haidian District,Beijing,100084,China [2]Department of Cardiology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing,100050,China [3]Tsinghua-Peking Center for Life Sciences,Tsinghua University,Beijing,100084,China [4]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,430071,China [5]The CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China [6]University of Chinese Academy of Sciences,Beijing,100049,China

出　　处：《Acta Pharmacologica Sinica》2023年第1期255-257,共3页中国药理学报（英文版）

基　　金：This work was supported by Beijing Natural Science Foundation(M21016 to SZ);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-003 to SZ);CAMS Innovation Fund for Medical Sciences(2021-CAMS-JZ004 to SZ);Tsinghua University-Peking University Center for Life Sciences(045-61020100122 to SYZ);Institute of biomedicine,Tsinghua University.

摘　　要：Dear Editor,The coronavirus pandemic has brought public health challenges worldwide.The main protease(M^(pro)),also called 3CL^(pro)(3C-like protease),is encoded by the gene of non-structural protein 5(nsp5).It is an attractive antiviral drug target to halt the progress of severe acute respiratory syndrome coronavirus-2(SARS-COV-2),the causative pathogen of coronavirus disease 2019(COVID-19)[1].After viral infection in host cells,the replicase gene encodes two polyproteins,pp1a(486 kDa)and pp1ab(790 kDa).

关 键 词：DRUG ACUTE RESPIRATORY 

分 类 号：R37[医药卫生—病原生物学]