益气通络法治疗急性脑梗死溶栓后疗效评价  

Evaluation of therapeutic efficacy of Yiqi Tongluo Formula on acute cerebral infarction after thrombolysis

作　　者：王政霞 姜远飞[2] 郭延林[2] WANG Zhengxia;JIANG Yuanfei;GUO Yanin(Clinical Skills Center,the Second Affiliated Hospital of Shandong First Medical University,Shandong,Taian271000,China;Department of Encephalopathy,Taian Traditional Chinese Medicine Hospital,Shandong,Taian271000,China)

机构地区：[1]山东第一医科大学第二附属医院临床技能中心,山东泰安271000 [2]山东省泰安市中医医院脑病科,山东泰安271000

出　　处：《中国医药科学》2023年第4期79-82,共4页China Medicine And Pharmacy

摘　　要：目的评价益气通络法治疗急性脑梗死溶栓后的临床疗效。方法将泰安市中医医院脑病科2010年6月至2015年6月入院的120例急性脑梗死符合尿激酶静脉溶栓标准的患者按随机数表法分为治疗组和对照组,每组各60例,两组患者均给予尿激酶静脉溶栓及溶栓后常规药物、康复治疗,治疗组在此基础上给予益气通络方治疗。观察两组患者溶栓后不良事件发生情况及治疗前后基质金属蛋白酶(MMP-9)、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)变化情况。结果治疗组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗组再闭塞与脑出血例数低于对照组,差异有统计学意义(P<0.05);治疗后MMP-9、hs-CRP、D-D含量比较,治疗组均低于对照组,差异均有统计学意义(P<0.05)。结论益气通络法用于急性脑梗死溶栓后患者的治疗,可显著降低不良事件发生,提高临床疗效。Objective To evaluate the clinical efficacy of Yiqi Tongluo Formula on acute cerebral infarction after thrombolysis.Methods A total of 120 patients with acute cerebral infarction meeting the criteria of intravenous thrombolysis with urokinase admitted to the Department of Encephalopathy of Taian Traditional Chinese Medicine Hospital from June 2010 to June 2015 were divided into the treatment group(n=60)and the control group(n=60)according to the random number table method.Both groups of patients were treated with intravenous thrombolysis with urokinase,and conventional drugs and rehabilitation therapy after thrombolysis.And the treatment group was given Yiqi Tongluo Formula on the above basis.Adverse events after thrombolysis and changes of matrix metalloproteinase(MMP-9),high-sensitivity C-reactive protein(hs-CRP)and D-dimer(D-D)before and after treatment were observed in the two groups.Results The overall response rate of the treatment group was higher than that of the control group,with statistically significant difference(P<0.05).The cases of re-occlusion and cerebral hemorrhage in the treatment group were both lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the content levels of MMP-9,hs-CRP and D-D in the treatment group were all lower than those in the control group,all with statistically significant differences(P<0.05).Conclusion Yiqi Tongluo Formula is used to treat patients with acute cerebral infarction after thrombolysis,which can significantly reduce the occurrence of adverse events and improve clinical efficacy.

关 键 词：益气通络法 急性脑梗死 静脉溶栓 不良事件 基质金属蛋白酶 超敏C反应蛋白 D-二聚体 

分 类 号：R743.33[医药卫生—神经病学与精神病学]