胼胝体发育不全胎儿半球间前连合宽度的MR初探  

Preliminary MR study of the width of anterior commissure in fetus with agenesis of corpus callosum

作　　者：石丽莉[1] 李素荣[1] 孙静涛[1] 李光民[1] 王婷 SHI Li-li;LI Su-rong;SUN Jing-tao;LI Guang-min;WANG Ting(Department of Radiology,Tangshan Maternal and Child Health Hospital,Hebei 063000,China)

机构地区：[1]唐山市妇幼保健院放射科,河北唐山063000

出　　处：《影像诊断与介入放射学》2023年第1期32-36,共5页Diagnostic Imaging & Interventional Radiology

摘　　要：目的 探讨胼胝体发育不全(ACC)胎儿的前连合宽度与正常胎儿是否存在差异。方法 回顾性收集2018年8月~2022年3月的42例行胎儿MR检查诊断为ACC,且具有产后影像学资料或上级医院会诊结果的胎儿为研究组,行胎儿MRI检查孕周为24~30周,按照研究组孕周收集同期行胎儿MR检查,并诊断为正常胎头的42例做为对照组;根据是否合并其他颅内畸形,将研究组分为单纯ACC组和ACC合并其他畸形组。所有病例均于Haste-T2WI轴位、TrufiT2WI轴位薄扫序列测量半球间前连合的宽度,分别比较对照组与研究组、单纯ACC组与ACC合并其他畸形组的前连合宽度是否存在差异,采用独立样本t检验进行统计学分析。结果 42例ACC胎儿中前连合均正常显示,胼胝体完全缺如36例,部分缺如6例。单纯ACC组27例;ACC合并其他畸形组共15例,其中合并半球间裂囊肿3例,Dandy-Walker畸形3例,脑积水2例,室管膜下囊肿2例,透明隔缺失、前脑无裂、Blake囊肿、小脑半球发育不良及脑室内出血各1例;研究组前连合宽(3.49±0.82) mm,对照组前联合宽(2.20±0.35) mm,对照组与研究组间比较差异存在统计学意义(P<0.001)。单纯ACC组前联合宽约(3.45±0.78) mm,ACC合并其他畸形组前联合宽(3.56±0.91) mm,两者间比较差异无统计学意义(P>0.05)。结论 ACC胎儿前连合存在,MR检查胼胝体发育不全胎儿的半球间前连合宽度较正常胎儿增宽,与是否伴发其他颅内畸形无关。Objective To compare the width of anterior commissures of fetuses with and without agenesis of corpus callosum(ACC). Methods MRI performed at the gestational age of 24-30 weeks on 84 fetuses with(42) and without(42) postnatal MR imaging diagnosis of ACC from August 2018 to March 2022 was retrospectively analyze. The width of anterior commissure was measured on the axial thin-slice half-Fourier acquisition single-shot turbo spin-echo(HASTE) and balanced steady-state gradient-echo(true FISP)-T2-weighted images. Independent sample t test was used for statistical comparison between the 2 groups. Results The anterior commissures were displayed clearly in 42 fetuses with complete(36) or partial(6) ACC. Of the 42 fetuses with ACC, 15 had other intracranial malformations including hemispheric cleft cyst(3), Dandy-Walker malformation(3), hydrocephalus(2), ependymal cyst(2), agenesis of septum pellucidum(1), forebrain dehiscence(1), Blake ’s pouch cyst(1), cerebellar hemisphere dysplasia(1), and intraventricular hemorrhage(1). The anterior commissure was significantly wider(P<0.001) in fetuses with ACC [(3.49±0.82) mm] than that without ACC[(2.20±0.35) mm]. There was no significant difference(P>0.05) in the anterior commissure width of ACC group without [(3.45±0.78) mm]and with other malformations [(3.56±0.91) mm]. Conclusion The anterior commissure of fetus with ACC is wider than that of normal fetus. There is no relationship between the anterior commissure width and other intracranial malformations.

关 键 词：胎儿 胼胝体 前连合 磁共振成像 产前诊断 

分 类 号：R714.5[医药卫生—妇产科学] R742[医药卫生—临床医学] R445.2