系统中医化疗保健操对食管癌患者化疗后消化道反应及生存质量的影响  

Effect of systemic Traditional Chinese Medicine chemotherapy health exercises on gastrointestinal reactions and survival quality in patients with esophageal cancer after chemotherapy

作　　者：韩辰燕[1] 董昀[1] 窦双婷 刘晓芯[2] HAN Chenyan;DONG Yun;DOU Shuangting;LIU Xiaoxin(Department of Integrated Traditional Chinese and Western Medicine,Shanghai Chest Hospital,Shanghai 200030,China;Department of Nursing,Shanghai Chest Hospital,Shanghai 200030,China)

机构地区：[1]上海市胸科医院中西医结合科,上海市200030 [2]上海市胸科医院护理部,上海市200030

出　　处：《广西医学》2023年第2期147-151,共5页Guangxi Medical Journal

基　　金：国家自然科学基金(81904114);上海交通大学中国医院发展研究院医院管理建设项目(CHDI-2022-B-26);上海交通大学医学院护理科研项目(Jyhz2037);上海交通大学护理学院高原学科建设国际交流基金项目(Hlgy1859qnhb);上海市胸科医院科技发展基金课题(YZ16-H03)。

摘　　要：目的分析系统中医化疗保健操对食管癌患者化疗后消化道反应及生存质量的影响。方法选取行泰素?+卡铂方案化疗的99例食管癌患者,将其随机分为研究组(n=51)与对照组(n=48)。两组患者均接受常规化疗护理,研究组同时接受系统中医化疗保健操干预。于化疗后3 d、7 d、14 d评估两组患者的消化道反应情况,并于化疗前7 d、化疗后7 d、化疗后21 d采用Karnofsky功能状态(KPS)评分对两组患者的生存质量进行评价。结果(1)在化疗后3 d、7 d,研究组的便秘、恶心/呕吐发生率均低于对照组(均P<0.05)。(2)化疗后7 d、21 d,研究组KPS评分均高于对照组(均P<0.05)。对照组KPS评分有随着时间延长而下降的趋势(均P<0.05),而研究组化疗前后的KPS评分差异无统计学意义(均P>0.05)。结论系统中医化疗保健操可有效减轻食管癌患者化疗后恶心、呕吐、便秘等消化道反应,并可提高其生存质量。Objective To analyze the effect of systemic Traditional Chinese Medicine chemotherapy health exercises on gastrointestinal reactions and survival quality in patients with esophageal cancer after chemotherapy.Methods A total of 99 patients with esophageal cancer undergoing Taxol?+carboplatin regimen for chemotherapy were selected,and they were randomly assigned to research group(n=51)or control group(n=48).Routine chemotherapy nursing was given to both groups;simultaneously,the research group received systemic Traditional Chinese Medicine chemotherapy health exercises for intervention.Gastrointestinal reactions were evaluated in both groups 3,7 and 14 days after chemotherapy,and the survival quality was evaluated in both groups by the Karnofsky Performance Status(KPS)score 7 days before chemotherapy,and 7 and 21 days after chemotherapy.Results(1)The research group exhibited lower incidence rates of constipation and nausea/vomiting as compared with the control group 3 and 7 days after chemotherapy(all P<0.05).(2)The research group depicted a higher score of KPS compared to the control group 7 and 21 days after chemotherapy(all P<0.05).The KPS score of the control group interpreted a decreased tendency over time(all P<0.05),whereas no statistically significant difference in KPS score of the research group between before chemotherapy and after chemotherapy(all P>0.05).Conclusion Systemic Traditional Chinese Medicine chemotherapy health exercises can effectively reduce gastrointestinal reactions with respect to nausea,vomiting and constipation,etc.in patients with esophageal cancer after chemotherapy,and improve their survival quality.

关 键 词：食管癌 系统中医化疗保健操 化疗 消化道反应 Karnofsky功能状态评分 生存质量 

分 类 号：R735.1[医药卫生—肿瘤]