虫草多糖的结构特征及其抗肿瘤活性  

Structural characteristics and antitumor activity of polysaccharides from Cordyceps species

作　　者：詹忠根[1] 叶素丹[1] 黄伟素[1] ZHAN Zhong-gen;YE Su-dan;HUANG Wei-su(Biopharmaceutical Laboratory,Zhejiang Institute of Economics and Trade,Hangzhou 310018,China)

机构地区：[1]浙江经贸职业技术学院,生物制药教研室,浙江杭州310018

出　　处：《药学学报》2023年第2期285-297,共13页Acta Pharmaceutica Sinica

基　　金：浙江省省属高校基本科研业务费项目(21SBYB08);浙江省自然科学基金(LGN18C200026).

摘　　要：多糖是虫草的主要生物活性成分之一,具有较强的抗肿瘤活性,能抑制神经母细胞瘤、黑色素瘤、肺癌、结肠癌等多种癌症。最近几十年来,虫草多糖已引起生物医学领域的极大关注,并吸引了众多学者开展相关研究。文章在分析虫草多糖结构特征的基础上,从增强免疫调节作用、抑制肿瘤细胞生长、降低肿瘤转移风险等3个方面综述了虫草多糖的抗肿瘤作用机制,并提出未来亟待深入研究的科学问题,以期为后续研究提供参考。Polysaccharides is one of the main bioactive components of Cordyceps species,because of the potential clinical value with stronger anti-tumor,such as anti-neuroblastoma,anti-melanoma,anti-lung cancer,anticolon cancer and so on,its have received widespread attention in biomedical field and increasing research in last decades.According to structural elucidation,this review gives a systematic literature overview on antitumor mechanism of Cordyceps species-derived polysaccharides from three aspects,including inhibition of tumor cell growth,enhancement of immunomodulatory activity and reduction of tumor metastasis.Finally,it also puts forward some scientific problems for follow up research.

关 键 词：虫草多糖 结构特征 抗肿瘤活性 免疫调节 细胞凋亡 

分 类 号：R966[医药卫生—药理学]