Structure, biochemical function, and signaling mechanism of plant NLRs  

作　　者：Jizong Wang Wen Song Jijie Chai 

机构地区：[1]State Key Laboratory of Protein and Plant Gene Research,School of Advanced Agricultural Sciences,Peking University,Beijing 100871,China [2]Tsinghua-Peking Joint Center for Life Sciences,Center for Plant Biology,School of Life Sciences,Tsinghua University,Beijing 100084,China [3]Institute of Biochemistry,University of Cologne,50674 Cologne,Germany [4]Max Planck Institute for Plant Breeding Research,50829 Cologne,Germany [5]Peking University Institute of Advanced Agricultural Sciences,Shandong Laboratory of Advanced Agricultural Sciences at Weifang,Weifang,Shandong 261000,China

出　　处：《Molecular Plant》2023年第1期75-95,共21页分子植物（英文版）

基　　金：Young Elite Scientists Sponsorship Program by CAST(grant YESS20210018 to J.W.);National Natural Science Foundation of China(grant 32271253 to J.W.);Alexander von Humboldt Foundation(professorship to J.C.);Max-Planck-Gesellschaft(a Max Planck fellowship to J.C.);Deutsche Forschungsgemeinschaft(grant SFB-1403-414786233 to J.C.);Germany's Excellence Strategy CEPLAS(EXC-2048/1,project 390686111 to J.C.).

摘　　要：To counter pathogen invasion,plants have evolved a large number of immune receptors,including membrane-resident pattern recognition receptors(PRRs)and intracellular nucleotide-binding and leucine-rich repeat receptors(NLRs).Our knowledge about PRR and NLR signaling mechanisms has expanded significantly over the past few years.Plant NLRs form multi-protein complexes called resistosomes in response to pathogen effectors,and the signaling mediated by NLR resistosomes converges on Ca2+-permeable channels.Ca2+-permeable channels important for PRR signaling have also been identified.These findings highlight a crucial role of Ca2+in triggering plant immune signaling.In this review,we first discuss the structural and biochemical mechanisms of non-canonical NLR Ca2+channels and then summarize our knowledge about immune-related Ca2+-permeable channels and their roles in PRR and NLR signaling.We also discuss the potential role of Ca2+in the intricate interaction between PRR and NLR signaling.

关 键 词：plant immunity PRR NLR resistosome Ca2+-permeable channels Ca2+signaling second messenger 

分 类 号：R73[医药卫生—肿瘤]