子宫内膜癌患者血清结缔组织生长因子、乙二醛酶Ⅰ、丙酮酸激酶M2水平变化及与临床病理特征的关系  

Expression of serum connective tissue growth factor, glyoxalase Ⅰ, pyruvate kinase M2 in endometrial carcinoma and its relationship with clinicopathological features

作　　者：陈利平 滕芸[1] 张娟[2] Chen Liping;Teng Yun;Zhang Juan(Department of Obstetrics and Gynecology,Yuechi County People′s Hospital,Guang′an 638300,China;Department of Gynecology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]岳池县人民医院妇产科,广安638300 [2]川北医学院附属医院妇科,南充637000

出　　处：《中国医师进修杂志》2023年第2期180-184,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的:探讨子宫内膜癌患者血清结缔组织生长因子(CTGF)、乙二醛酶Ⅰ(GLO-Ⅰ)、丙酮酸激酶M2(PKM2)水平变化及与临床病理特征的关系。方法:选取岳池县人民医院2015年2月至2017年2月诊治的96例子宫内膜癌患者作为研究组,另选取同期48例子宫内膜增生患者作为良性对照组,同期48例健康体检者作为健康对照组,比较三组血清CTGF、GLO-Ⅰ、PKM2水平,分析子宫内膜癌患者血清CTGF、GLO-Ⅰ、PKM2水平之间的相关性,分析CTGF、GLO-Ⅰ、PKM2水平与子宫内膜癌临床病理特征的关系。结果:研究组血清CTGF、GLO-Ⅰ、PKM2水平高于良性对照组和健康对照组[(184.31±37.14)μg/L比(110.45±20.59)和(17.28±0.42)μg/L、(95.17±16.56)pmol/L比(56.29±10.14)和(9.08±0.66)pmol/L、(20.25±6.13)μg/L比(13.11±4.58)和(9.05±2.74)μg/L],良性对照组血清CTGF、GLO-Ⅰ、PKM2水平高于健康对照组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,子宫内膜癌患者血清CTGF水平与GLO-Ⅰ、PKM2水平呈正相关(r=0.713、0.741,P<0.05),GLO-Ⅰ水平与PKM2水平呈正相关(r=0.823,P<0.05)。Spearman相关性分析结果显示,血清CTGF、GLO-Ⅰ、PKM2水平与FIGO分期(r=0.609、0.704、0.721,P<0.05)、肌层浸润深度(r=0.753、0.695、0.719,P<0.05)、淋巴结转移(r=0.776、0.744、0.640,P<0.05)呈正相关,与分化程度呈负相关(r=-0.711、-0.720、-0.668,P<0.05)。结论:子宫内膜癌患者血清CTGF、GLO-Ⅰ、PKM2水平异常升高,并与多项临床病理特征相关。Objective To explore the expression of serum connective tissue growth factor(CTGF),glyoxalaseⅠ(GLO-I)and pyruvate kinase M2(PKM2)in endometrial cancer and their relationship with clinicopathological characteristics.Methods A total of 96 endometrial cancer patients in Yuechi County People's Hospital from February 2015 to February 2017 were selected as the research group,48 patients with endometrial hyperplasia during the same period were selected as the benign control group,and 48 patients with healthy physical examination during the same period were selected as the healthy control group.The serum levels of CTGF,GLO-Ⅰ,and PKM2 in the three groups were analyzed.The correlation between serum levels of CTGF,GLO-Ⅰand PKM2 in the research group was analyzed,and the relationship between each serum index and clinicopathological characteristics was analyzed.Results The levels of serum CTGF,GLO-Ⅰand PKM2 in the research group were higher than those in the benign control group and healthy control group:(184.31±37.14)μg/L vs.(110.45±20.59),(17.28±0.42)μg/L;(95.17±16.56)pmol/L vs.(56.29±10.14),(9.08±0.66)pmol/L;(20.25±6.13)μg/L vs.(13.11±4.58),(9.05±2.74)μg/L;and the levels of serum CTGF,GLO-Ⅰand PKM2 in the benign control group were higher than those in the healthy control group,there were statistical differences(P<0.05).The results of Pearson correlation analysis showed that the level of CTGF had positive correlation with GLO-Ⅰand PKM2(r=0.713,0.741,P<0.05),and the level of GLO-Ⅰhad positive correlation with PKM2(r=0.823,P<0.05).The results of Spearman correlation analysis showed that the levels of CTGF,GLO-Ⅰ,PKM2 had positive correlation with FIGO stage(r=0.609,0.704,0.721;P<0.05),myometrial invasion depth(r=0.753,0.695,0.719;P<0.05),lymph node metastasis(r=0.776,0.744,0.640;P<0.05);had negative correlation with the degree of differentiation(r=-0.711,-0.720,-0.668;P<0.05).Conclusions Serum CTGF,GLO-I,PKM2 expression levels are abnormally elevated in patients with endometrial cancer,which are si

关 键 词：子宫内膜肿瘤 病理状态 体征和症状 结缔组织生长因子 乙二醛酶Ⅰ 丙酮酸激酶M2 

分 类 号：R737.33[医药卫生—肿瘤]