Diverse catalytic systems for nitrogen-heterocycle formation from O-acyl ketoximes  

作　　者：Zhonghua Qu Tong Tian Guo-Jun Deng Huawen Huang 

机构地区：[1]Key Laboratory for Green Organic Synthesis and Application of Hunan Province,Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan 411105,China [2]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China

出　　处：《Chinese Chemical Letters》2023年第1期19-28,共10页中国化学快报（英文版）

基　　金：Financial support by the National Natural Science Foundation of China(No.22071211);the Science and Technology Planning Project of Hunan Province(No.2019RS2039);Hunan Provincial Natural Science Foundation of China(No.2020JJ3032);Scientific Research Fund of Education Department of Hunan Province(No.21A0079);Open Research Fund of School of Chemistry and Chemical Engineering of Henan Normal University(No.2022C02)。

摘　　要：O-Acyl ketoximes has been proven to be versatile building blocks for practical construction of Nheterocycles.In the last few years,diverse catalytic systems have been discovered to enable efficient transformations of O-acyl ketoximes to a range of nitrogen-heterocycles.Herein,we summarized our recent examples of novel nitrogen-heterocycle formation with new function findings of O-acyl ketoximes through facile aerobic copper catalysis,metal-free N–O bond activation,multi-component assembly,and bis-annulations.From the green chemistry perspective,these works represent efficient methods with high atom economy,high selectivity,and minimized chemical waste.These findings also complement well to the previous mainly copper-based catalytic systems and more importantly enrich the oxime chemistry in organic synthesis.

关 键 词：Nitrogen-heterocycle O-Acyl ketoximes ANNULATIONS Copper catalysis Metal-free Multi-component 

分 类 号：O64[理学—物理化学]