Atramacronoids A-C,three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C-C linkage from the rhizomes of Atractylodes macrocephala  

作　　者：Haixin Zhang Jingrong Li Jinguang Si Chengya Dong Qi Li Meng Yu Lingling Qin Lingyu Li Chenxu Zhao Tao Zhang Zhongmei Zou 

机构地区：[1]Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China [2]Medical Sciences,Guizhou Medical University,Guiyang 550000,China [3]China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing 100193,China [4]School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450000,China

出　　处：《Chinese Chemical Letters》2023年第1期284-288,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82073992);the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-071)。

摘　　要：Three eudesmanolide sesquiterpene-phenol hybrids,atramacronoids A-C(1-3),featuring an unusual6/6/5/5/6 skeleton furnished by forming an unexpected C-8-C-16 linkage,were obtained from the rhizomes of Atractylodes macrocephala.Their structures and absolute configurations were elucidated by spectroscopic data analysis,chemical calculations,combined with X-ray diffractions.The plausible biosynthetic pathways for compounds 1-3 are proposed.Surprisingly,compound 1 exhibited cytotoxicity against SGC-7901 cells by inducing cells apoptosis,which might relate to the promotion of synthesis of neutrophil elastase.

关 键 词：Atractylodes macrocephala COMPOSITAE Sesquiterpene-phenol hybrids ANTI-CANCER Neutrophil elastase 

分 类 号：O62[理学—有机化学]