Polyaniline-supported tungsten-catalyzed oxidative deoximation reaction with high catalyst turnover number  

作　　者：Wen Li Feng Wang Yaocheng Shi Lei Yu 

机构地区：[1]School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China

出　　处：《Chinese Chemical Letters》2023年第1期347-350,共4页中国化学快报（英文版）

基　　金：Jiangsu Provincial Six Talent Peaks Project(No.XCL-090);Natural Science Foundation of Jiangsu Province(No.BK20181449);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)for support。

摘　　要：Polyaniline-supported tungsten(W@PANI)was easily prepared by immersing polyaniline(PANI)in the aqueous solution of Na2WO4.It was found to be an efficient catalyst for oxidative deoximation reaction,the very important transformation for pharmaceutical industry.Besides the green features,the method employed very few of catalytic tungsten(0.048 mol%vs.oxime substrates),resulting in the high turnover numbers(TONs)of the catalyst(ca.103 mol/mol)and the low metal residues in product(<0.1 ppm).The reaction is applicable for a variety of substrates,including those containing heterocycles,which are key intermediates in medicine synthesis.It has also been successfully magnified to kilogram scale production to afford the desired carbonyl products smoothly.

关 键 词：DEOXIMATION CARBONYL TUNGSTEN Free radical reaction Oxidation 

分 类 号：O62[理学—有机化学]