N-Heterocyclic carbene catalyzed C-acylation reaction for access to linear aminoenones  

作　　者：Jie Lv Yingling Nong Kai Chen Qingyun Wang Jiamiao Jin Tingting Li Zhichao Jin Yonggui Robin Chi 

机构地区：[1]State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering,Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education,Guizhou University,Guiyang 550025,China

出　　处：《Chinese Chemical Letters》2023年第1期357-361,共5页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(Nos.21772029,32172459,21961006,22001173);The 10 Talent Plan(Shicengci)of Guizhou Province(No.[2016]5649);the Science and Technology Department of Guizhou Province(Nos.[2019]1020,Qiankehejichu-ZK[2021]Key033);the Program of Introducing Talents of Discipline to Universities of China(111 Program,No.D20023)at Guizhou University;Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[No.Qianjiaohe KY(2020)004];the Guizhou Province First-Class Disciplines Project(No.GNYL(2017)008);Guizhou University(China)。

摘　　要：An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone products.Theβ-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions.The reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.

关 键 词：N-Heterocyclic carbene ORGANOCATALYSIS C-Acylation reaction Animoenone synthesis 

分 类 号：O621.251[理学—有机化学]