Application of Serum Apelin and MMP-9 in Evaluation of Silicosis and Their Correlation with Lung Function  

作　　者：Gaocai XIONG Yuanfeng YANG Jiasong LI Tingqian LIU Bingbing HE Zhuoling LIU 

机构地区：[1]The Third People s Hospital of Guizhou Province,Guiyang 550000,China [2]Department of Pharmacy,The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China

出　　处：《Agricultural Biotechnology》2023年第1期39-42,共4页农业生物技术（英文版）

基　　金：Supported by Science and Technology Fund Project of Guizhou Provincial Health Commission (gzwjkj2020-1-184)。

摘　　要：[Objectives]This study was conducted to explore the combination of serum Apelin and MMP-9 in the assessment of silicosis and their correlation with lung function. [Methods] From January 2020 to January 2021, eight patients with silicosis(including 3, 2 and 3 patients with silicosis in stages I, II and III respectively) were selected as the observation group, and eight persons frees of silicosis were selected as the control group during the same period. All patients were detected for serum APJ endogenous ligand(Apelin) of G protein-coupled receptor, matrix metalloproteinase-9(MMP-9) and pulmonary function indexes. The levels of serum Apelin and MMP-9 and lung function in the two groups were compared, and the correlation between serum Apelin and MMP-9 indexes and lung function was analyzed. [Results] The serum Apelin and lung function in the observation group were lower than those in the control group, and the level of MMP-9 in the observation group was higher than that in the control group, and the differences were statistically significant(P<0.05). The MMP-9 index in patients with silicosis in stage III was higher than those in patients with silicosis in stage II and stage I, and the MMP-9 index in patients with silicosis in stage II was higher than that in patients with silicosis in stage I, and the differences were statistically significant(P<0.05). The serum Apelin and lung function indexes of patients with silicosis in stage III were lower than those of patients with silicosis in stage II and stage I, and the serum Apelin and lung function indexes of patients with silicosis in stage II were lower than those of patients with silicosis in stage I, and the differences were statistically significant(P<0.05). The correlation analysis showed a positive correlation between serum Apelin and lung function indexes, and a negative correlation between MMP-9 and lung function indexes. [Conclusions] A lower serum Apelin and a higher MMP-9 value in patients with silicosis indicate severer lung function impairment, and the c

关 键 词：Serum Apelin MMP-9 SILICOSIS Condition assessment Pulmonary function Correlation study 

分 类 号：R563[医药卫生—呼吸系统]