NOTCH信号通路在口腔癌中的研究进展  

Research progress of NOTCH signaling pathway in oral cancer

作　　者：熊晓雪 廖成成 刘建国 向明丽 郭秋爽 龙思岑 岳超弈 管晓燕 XIONG Xiaoxue;LIAO Chengcheng;LIU Jianguo;XIANG Mingli;GUO Qiushuang;LONG Sicen;YUE Chaoyi;GUAN Xiaoyan(Affiliated Stomatological Hospital of Zunyi Medical University,Guizhou Zunyi 563000,China;Guizhou Provincial Key Laboratory of Oral Disease Research in Colleges and Universities,Guizhou Zunyi 563000,China;West China School of Stomatology,Sichuan University,Sichuan Chengdu 610000,China;School of Medicine and Science,Zunyi Medical University,Guizhou Zunyi 563000,China)

机构地区：[1]遵义医科大学附属口腔医院,贵州遵义563000 [2]贵州省普通高等学校口腔疾病研究特色重点实验室,贵州遵义563000 [3]四川大学华西口腔医学院,四川成都610000 [4]遵义医科大学医学与科技学院,贵州遵义563000

出　　处：《现代肿瘤医学》2023年第6期1162-1165,共4页Journal of Modern Oncology

基　　金：国家重点研发计划项目(编号:2016YFC1102800);国家自然科学基金项目(编号:82060205);贵州省医用生物材料研发人才基地项目(编号:黔人领发[2018]3号);贵州省普通高等学校青年科技人才成长项目(编号:黔教合KY字[2021]215)。

摘　　要：NOTCH信号通路是一种保守的分子通路,对组织稳态至关重要。口腔鳞状细胞癌(oral squamous cell carcinoma, OSCC)是最常见的实体肿瘤之一,其NOTCH信号通路发生改变促进了肿瘤细胞增殖、迁移、耐药等生物学恶性行为。并且,NOTCH信号通路参与了OSCC发生的关键致瘤事件,包括对异常血管生成、肿瘤干细胞更新和上皮间充质转化的调节。因此,NOTCH信号通路可能是调控OSCC形成的关键分子信号,并为OSCC靶向治疗提供了一个有希望的治疗靶点。The NOTCH signaling pathway is a conserved molecular pathway that is essential for tissue homeostasis.Oral squamous cell carcinoma(OSCC) is one of the most common solid tumors, and changes in its NOTCH signaling pathway promote biological malignant behaviors such as tumor cell proliferation, migration, and drug resistance.In this review, the NOTCH signaling pathway is involved in key tumorigenic events in OSCC,including regulation of abnormal angiogenesis, tumor stem cell turnover, and epithelial-mesenchymal transition.Therefore, the NOTCH signaling pathway may be a key molecular signal regulating OSCC formation and provide a promising therapeutic target for OSCC targeted therapy.

关 键 词：NOTCH信号通路 口腔鳞状细胞癌 肿瘤干细胞 上皮间充质转化 

分 类 号：R739.8[医药卫生—肿瘤]