不同病理类型肺癌组织中S100A6的表达情况及其临床意义  

Expression and Clinical Significance of S100A6 in Different Pathological Types of Lung Cancer Tissue

作　　者：张奕 王婷 刘蕊 ZHANG Yi;WANG Ting;LIU Rui(Department of Respiratory Medicine,Xi'an People's Hospital/Xi'an No.4 Hospital,Xi'an 710004,China)

机构地区：[1]陕西省西安市人民医院西安市第四医院呼吸内科,710004

出　　处：《实用心脑肺血管病杂志》2023年第3期21-24,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：陕西省重点研发计划项目(2022SF-539);西安市人民医院(西安市第四医院)孵化基金项目(授权号:FZ-75)。

摘　　要：目的探讨S100A6在不同病理类型肺癌组织中的表达情况及其临床意义。方法回顾性选取2019年1月至2022年1月就诊于西安市人民医院的98例经病理学明确诊断的肺癌患者的肺癌组织标本,其中腺癌48例、鳞癌40例、小细胞肺癌(SCLC)8例、大细胞肺癌2例,同时选取8例肺癌患者的癌旁正常组织。收集患者的性别、年龄、有无吸烟史、病理类型、临床分期、分化程度、肿瘤直径、有无淋巴结转移、临床疗效。采用免疫组化检测S100A6表达情况。结果不同性别、不同年龄、有无吸烟史、不同肿瘤直径、有无淋巴结转移、不同临床疗效的肺癌患者肺癌组织S100A6表达阳性率比较,差异无统计学意义(P>0.05);不同病理类型、临床分期、分化程度的肺癌患者肺癌组织S100A6表达阳性率比较,差异有统计学意义(P<0.05)。不同性别、不同年龄、有无吸烟史、不同分化程度、不同肿瘤直径、有无淋巴结转移、不同临床疗效的腺癌及鳞癌患者肺癌组织S100A6表达阳性率比较,差异无统计学意义(P>0.05);不同临床分期的腺癌及鳞癌患者肺癌组织S100A6表达阳性率比较,差异有统计学意义(P<0.05)。结论S100A6表达阳性率在不同病理类型、临床分期、分化程度肺癌患者肺癌组织中不同,S100A6表达阳性率在腺癌及鳞癌患者肺癌组织中表达升高,这可能与临床分期相关。Objective To investigate the expression and clinical significance of S100A6 in different pathological types of lung cancer tissue.Methods The lung cancer tissue samples of 98 patients with lung cancer confirmed by pathology in Xi'an People's Hospital from January 2019 to January 2022 were retrospectively selected,including 48 cases of adenocarcinoma,40 cases of squamous cell carcinoma,8 cases of small cell lung cancer(SCLC),and 2 cases of large cell lung cancer.At the same time,normal tissues adjacent to cancer of 8 lung cancer patients were selected.The gender,age,smoking history,pathological type,clinical stage,differentiation degree,tumor diameter,lymph node metastasis and clinical efficacy of the patients were collected.The expression of S100A6 was detected by immunohistochemistry.Results There was no significant difference in the positive rate of S100A6 expression of lung tissues among lung cancer patients with different gender,different age,smoking history,different tumor diameter,lymph node metastasis and different clinical efficacy(P>0.05);the positive rate of S100A6 expression of lung tissues in lung cancer patients with different pathological types,clinical stages and differentiation degrees was statistically significant(P<0.05).There was no significant difference in the positive rate of S100A6 expression of lung tissues in adenocarcinoma and squamous cell carcinoma patients with different gender,age,smoking history,differentiation degree,tumor diameter,lymph node metastasis and clinical efficacy(P>0.05);the positive rate of S100A6 expression of lung tissues in adenocarcinoma and squamous cell carcinoma patients with different clinical stages was statistically significant(P<0.05).Conclusion The positive rate of S100A6 expression of lung tissues in lung cancer patients with different pathological types,clinical stages and differentiation degrees is statistically significant,the positive rate of S100A6 expression of lung tissues is elevated in adenocarcinoma and squamous cell carcinoma patients,which may

关 键 词：肺肿瘤 小细胞肺癌 癌 非小细胞肺 鳞癌 肺腺癌 S100A6 

分 类 号：R734.2[医药卫生—肿瘤]