帕金森病与丝裂原活化蛋白激酶信号通路的相关性及中医药干预作用  

Correlation between Parkinson's Disease and MAPK Signaling Pathway and the Intervention Effect of Traditional Chinese Medicine

作　　者：曹媛媛[1] 孙灵芝[2] CAO Yuanyuan;SUN Lingzhi(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Neurology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东省济南市250014 [2]山东中医药大学附属医院神经内一科,250014

出　　处：《实用心脑肺血管病杂志》2023年第3期117-122,共6页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：山东省自然科学基金面上项目(ZR2021MH180)。

摘　　要：帕金森病(PD)是一种进行性多系统神经退行性疾病,其中黑质多巴胺能神经元丧失是其重要的病理改变。丝裂原活化蛋白激酶(MAPK)信号通路能调节细胞的生长、分化、凋亡、炎症等多种生理病理过程,近年来其已成为PD机制研究的热点。本文主要综述了PD与MAPK亚家族〔p38 MAPK、c-Jun氨基末端激酶(JNK)和细胞外信号调节激酶(ERK)〕的相关性及中医药干预作用,以期为PD的诊疗提供新的思路。Parkinson's disease(PD)is a progressive multisystem neurodegenerative disease in which loss of nigrostriatal dopaminergic neurons is an important pathological change.The mitogen-activated protein kinase(MAPK)signaling pathway regulates various physiopathological processes such as cell growth,differentiation,apoptosis,and inflammation,and it has become a hot spot for PD mechanism research in recent years.This paper mainly reviews the correlation between PD and MAPK subfamily[p38 MAPK,c-Jun amino-terminal kinase(JNK)and extracellular signal-regulated kinase(ERK)]and the intervention of Chinese medicine,in order to provide new ideas for the diagnosis and treatment of PD.

关 键 词：帕金森病 丝裂原活化蛋白激酶类 p38 MAPK信号通路 JNK信号通路 ERK信号通路 中医药 

分 类 号：R742.5[医药卫生—神经病学与精神病学]