真姬菇次生代谢产物化学成分研究  

Study on the Chemical Constituents of the Secondary Metabolites from Hypsizygus marmoreus

作　　者：肖咪 罗蓉[1] 薛宏坤 唐劲天[2] 柳鑫 苏彦奇 蔡旭 XIAO Mi;LUO Rong;XUE Hong-kun(Union Jiangbei Hospital,Huazhong University of Science and Technology/Medicament Department,Wuhan Caidian People’s Hospital,Wuhan,Hubei 430065;Key Laboratory of Particle&Radiation Imaging,Ministry of Education,Department of Engineering Physics,Tsinghua University,Beijing 100084)

机构地区：[1]华中科技大学协和江北医院/武汉市蔡甸区人民医院药剂科,湖北武汉430065 [2]清华大学工程物理系教育部粒子与辐射成像重点实验室,北京100084 [3]武汉市第四医院药剂科,湖北武汉430034

出　　处：《安徽农业科学》2023年第3期180-183,共4页Journal of Anhui Agricultural Sciences

基　　金：武汉市卫生计生委科研计划项目(WZ21Q15)。

摘　　要：[目的]研究真姬菇次生代谢产物的化学成分。[方法]真姬菇通过大米培养发酵、乙酸乙酯提取后,获得提取物。提取物经硅胶柱、Sephadex LH-20凝胶柱、RP-C 18反相硅胶柱等分离纯化,根据波谱数据与文献对比解析化合物结构。[结果]从真姬菇大米发酵的乙酸乙酯提取物中分离得到了14个化合物,分别鉴定为羟基大黄素(1)、1,8-二羟基蒽醌(2)、大黄素(3)、大黄素甲醚(4)、1-羟基-2-甲基蒽醌(5)、2,4-二羟基苯甲酸甲酯(6)、4-羟基苯甲酸甲酯(7)、(2ALPHA)-A′-新伽马蜡烷-2,22-二醇(8)、β-谷甾醇(9)、豆甾醇(10)、麦角甾-4,6,8(14),22-四烯-3-酮(11)、麦角甾-7,22-二烯-3-酮(12)、硬脂酸(13)、油酸(14)。[结论]化合物1~14均为首次从玉蕈属真菌次生代谢产物中分离得到。[Objective]To study the chemical constituents of the secondary metabolites from Hypsizygus marmoreus.[Method]The fermented rice substrate of Hypsizygus marmoreus was extracted by using ethyl acetate,then separated and purified through silica gel,Sephadex LH-20 column and RP-C 18 column.Compared with the reports,the structures of isolated compounds were identified according to spectral data.[Result]Totals of 14 compounds were isolated from the ethyl acetate extraction of Hypsizygus marmoreus,which were identified as citreorosein(1),1,8-Dihydroxyanthraquinone(2),emodin(3),physcion(4),1-Hydroxy-2-methylanthraquinone(5),methyl 2,4-dihydroxybenzoate(6),4-Hydroxybenzoic acid methyl ester(7),2-hydroxydiplopterol(8),β-Sitosterol(9),stigmasterol(10),(22E)-ergosta-4,6,8(14),22-tetraen-3-one(11),ergosta-7,22-dien-3-one(12),stearic acid(13),oleic acid(14).[Conclusion]Compounds 1-14 are isolated from the genus Hypsizygus for the first time.

关 键 词：真姬菇 次生代谢产物 化学成分 

分 类 号：R284.1[医药卫生—中药学]