三维斑点追踪技术对乳腺癌术后化疗左室心肌功能损害的诊断价值  

Diagnostic value of 3 dimensional speckle tracking imaging on left ventricular dysfunction during postoperative chemotherapy for breast cancer

作　　者：赵建颖 朱亮飞 李悦 ZHAO Jian-ying;ZHU Liang-fei;LI Yue(Department of Ultrasound,Foshan Nanhai Traditional Chinese Medicine Hospital,Foshan 528200,China;Department of Medical Imaging,Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Foshan Nanhai Traditional Chinese Medicine Hospital,Foshan 528200,China)

机构地区：[1]广东省中西医结合医院(佛山市南海区中医院)超声诊断科 [2]广东省中西医结合医院(佛山市南海区中医院)医学影像科,广东佛山528200

出　　处：《广东医科大学学报》2023年第1期31-34,共4页Journal of Guangdong Medical University

基　　金：佛山市科学技术局(2017AB000792)。

摘　　要：目的探究三维斑点追踪技术(3D-STI)对乳腺癌术后化疗左室心肌功能损害的诊断价值。方法65例乳腺癌患者(观察组)及20例健康志愿者(对照组)作常规二维超声、3D-STI检查,分析观察组化疗前后左室舒张末期容积(LVEDV)、左室收缩期末期容积(LVESV)、左室整体面积应变(GAS)、整体圆周应变(GCS)、整体径向应变(GRS)、整体纵向应变(GLS),采用受试者工作特征(ROC)曲线获取LVEDV、LVESV、GAS、GCS、GRS、GLS对左室心肌功能损害的评估效能。结果观察组化疗中期GAS、GLS水平低于化疗前(P<0.05)。化疗中期,当GAS、GLS截断值分别为31.0%、18.0%时,其诊断左室心肌功能损害ROC曲线的AUC分别为0.970、0.865,敏感度分别为93.9%、89.2%,特异度分别为95.0%、75.0%。结论3D-STI可应用于乳腺癌术后化疗患者左室心肌功能损害检测,GAS、GLS对乳腺癌患者化疗中期药物心肌毒性监测有重要意义。Objective To observe the diagnostic value of 3-dimensional speckle tracking imaging(3D-STI)on left ventricular dysfunction(LVD)during postoperative chemotherapy for breast cancer.Methods Two-dimensional ultrasound(2D-US)and 3D-STI were performed on 65 patients with breast cancer(observation group)and 20 healthy volunteers(control group).Left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV),left ventricular global area strain(GAS),global circumferential strain(GCS),global radial strain(GRS),global longitudinal strain(GLS)were observed before and after chemotherapy.The efficiency of LVEDV,LVESV,GAS,GCS,GRS,and GLS on LVD was evaluated by receiver operating characteristic(ROC)curves.Results GAS and GLS were lower during middle chemotherapy than before chemotherapy in observation group(P<0.05).The cut-off values of GAS and GLS were set at 31.0%and 18.0%during middle chemotherapy,their AUCs,sensitivity,and specificity for LVD diagnosis were 0.970,0.865;93.9%,89.2%;and 95.0%,75.0%;respectively.Conclusion 3D-STI can be applicable in LVD evaluation during postoperative chemotherapy for breast cancer,of which GAS and GLS are valuable for myocardial toxicity monitoring during middle chemotherapy.

关 键 词：三维斑点追踪技术 乳腺癌 化疗 

分 类 号：R737.9[医药卫生—肿瘤] R453.9[医药卫生—临床医学]