肠道微生物代谢产物短链脂肪酸对抑郁症的作用研究进展  

Research progress in effects of short-chain fatty acids in intestinal microbial metabolites on depression

作　　者：彭高强 文颖娟[1] 仝武宁 陈茉 吕建琴[2] 滕飞 Peng Gao-Qiang;Wen Ying-Juan;Tong Wu-Ning;Chen Mo;Lv Jian-Qin;Teng Fei(School of Basic Medicine,Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712046,China;Department of Integrated Traditional Chinese and Western Medicine,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China;State Key Laboratory of Biotherapy,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046 [2]四川大学华西医院中西医结合科,四川成都610041 [3]四川大学生物治疗国家重点实验室,四川成都610041

出　　处：《解放军医学杂志》2023年第2期224-230,共7页Medical Journal of Chinese People's Liberation Army

基　　金：国家重点研发计划(2017YFC1703506);国家自然科学基金(81202642)。

摘　　要：肠道微生物与抑郁症的发病关系密切,但其具体作用机制尚未完全阐明。短链脂肪酸(SCFA)是膳食纤维和抗性淀粉等植物多糖在肠道微生物介导下发酵产生的代谢产物,主要由乙酸、丙酸、丁酸组成,在微生物-肠-脑轴中起着重要的作用。近年来研究发现,SCFA不仅可调节肠道能量代谢,还可通过血脑屏障、免疫途径、内分泌通路及迷走神经等缓解抑郁症。SCFA是目前研究的重点,国内SCFA干预抑郁症的报道较少。本文综述了SCFA对抑郁症的作用研究进展,以期为临床研究提供新的思路。Intestinal microorganisms are closely related to the pathogenesis of depression, but their specific mechanism of action has not been fully explained. Short-chain fatty acids(SCFA) are metabolites produced by the fermentation of plant polysaccharides, such as dietary fiber and resistant starch mediated by gut microorganisms, which are mainly composed of acetic acid, propionic acid, and butyric acid, and play an important role in the microbiota-intestine-brain axis. Recent studies have found that SCFA can not only regulate intestinal energy metabolism, but also improve depression through blood-brain barrier, immune pathway, endocrine pathway and vagus nerve. SCFA is the focus of scientific research nowadays, and there are few reports on SCFA intervention in depression in China. This article reviews the research progress of SCFA on depression, providing new ideas for clinical research.

关 键 词：肠道微生物 短链脂肪酸 抑郁症 

分 类 号：R749[医药卫生—神经病学与精神病学]