小胶质细胞:血管性认知损害的潜在干预靶点  

Microglia: a potential intervention target for vascular cognitive impairment

作　　者：肖伊宁[1,2,3] 管天媛 吕佩源 Xiao Yining;Guan Tianyuan;Lyu Peiyuan(Graduate School of Hebei Medical University,Shijiazhuang 050017,China;Department of Neurology,Hebei General Hospital,Shijiazhuang 050017,China;Hebei Key Laboratory of Brain Network and Cognitive Disorders,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学研究生院,石家庄050017 [2]河北省人民医院神经内科,石家庄050051 [3]河北省脑网络与认知障碍疾病重点实验室,石家庄050051

出　　处：《国际脑血管病杂志》2022年第8期626-630,共5页International Journal of Cerebrovascular Diseases

摘　　要：小胶质细胞是中枢神经系统中的主要固有免疫细胞, 在中枢神经系统的发育和疾病发生中起着多种作用。近年来研究发现, 小胶质细胞在血管性认知损害(vascular cognitive impairment, VCI)的发生发展中发挥重要作用, 可通过激活神经炎症、氧化应激和破坏血脑屏障等机制导致认知功能减退。文章对小胶质细胞在VCI病理生理学中的作用进行综述, 旨在为靶向小胶质细胞治疗VCI提供新的依据。Microglia are the main innate immune cells in the central nervous system,which play a variety of roles in the development of the central nervous system and the occurrence of diseases.Recent studies have found that microglia play an important role in the occurrence and development of vascular cognitive impairment(VCI),which can lead to cognitive decline by activating neuroinflammation,oxidative stress,and destroying the blood-brain barrier.This article reviews the role of microglia in the pathophysiology of VCI,aiming to provide a new basis for targeting microglia to treat VCI.

关 键 词：认知障碍 脑血管意外 小胶质细胞 炎症 氧化应激 血脑屏障 

分 类 号：R749.13[医药卫生—神经病学与精神病学]