血肿消退:脑出血的治疗靶点  

Hematoma regression: a therapeutic target for intracerebral hemorrhage

作　　者：张冲 孟金城 金思楠 华威[1] 吴鹤[1] Zhang Chong;Meng Jincheng;Jin Sinan;Hua Wei;Wu He(Department of Pathology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院病理科,哈尔滨150001

出　　处：《国际脑血管病杂志》2022年第8期631-635,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(81671142)。

摘　　要：脑出血患者的残疾率和病死率极高,目前尚无有效治疗方法改善患者转归。血肿的机械性压迫和毒性产物释放是导致脑出血患者出现原发性和继发性脑损伤的主要原因,而安全和有效地加速血肿消退是改善脑出血患者神经功能缺损的关键策略。小胶质细胞/巨噬细胞是介导血肿清除的主要吞噬系统,主要极化为M1和M2表型。细胞表面受体以及可能存在的信号转导通路对小胶质细胞/巨噬细胞介导的内源性血肿消退发挥着重要的调控作用,可能成为今后临床治疗脑出血并改善患者转归的新靶点。The disability and mortality rate of patients with intracerebral hemorrhage are very high.At present,there is no effective treatment to improve the outcome of patients with intracerebral hemorrhage.Mechanical compression of hematoma and release of toxic products are the main causes of primary and secondary brain injury in patients with intracerebral hemorrhage,while safe and effective acceleration of hematoma regression is the key strategy to improve the neurological deficit in patients with intracerebral hemorrhage.Microglia/macrophages are the main phagocytic system that mediates hematoma clearance and are mainly polarized into M1 and M2 phenotypes.Cell surface receptors and possible signal transduction pathways play an important role in regulating the endogenous hematoma regression mediated by microglia/macrophages,and may become a new target for clinical treatment of intracerebral hemorrhage and improvement of the outcomes of patients in the future.

关 键 词：脑出血 血肿 小胶质细胞 巨噬细胞 吞噬作用 

分 类 号：R743.34[医药卫生—神经病学与精神病学]