强迫症患者额顶叶网络信息整合与分离功能特点  

The functional characteristics of frontoparietal network information integration and separation in patients with obsessive-compulsive disorder

作　　者：耿艺博 张红星 王晓岳 刘亚辉 武肖然 王雪可 常巧华 赵庆江[1] 张佳佳 张恩图 艾伦朴 张海三[1] Yibo Geng;Hongxing Zhang;Xiaoyue Wang;Yahui Liu;Xiaoran Wu;Xueke Wang;Qiaohua Chang;Qingjiang Zhao;Jiajia Zhang;Entu Zhang;Lunpu Ai;Haisan Zhang(The Second Affiliated Hospital Magnetic Resonance Department of Xinxiang Medical University,Henan Mental Hospital,Xinxiang Key Laboratory of Multimodal Brain Imaging,Xinxiang Mental Image Engineering Technology Research Center,Xinxiang 453002,China;Department of Psychology,Xinxiang Medical University,Xinxiang 453003,China;Department of Nursing,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]新乡医学院第二附属医院磁共振科,河南省精神病医院,新乡市多模态脑影像重点实验室,新乡市精神影像工程技术研究中心,新乡453002 [2]新乡医学院心理学院,新乡453003 [3]新乡医学院护理学院,新乡453003

出　　处：《中华精神科杂志》2023年第1期17-23,共7页Chinese Journal of Psychiatry

基　　金：国家自然科学基金联合基金(U1704190);新乡市科技攻关计划(GG2019040);河南省科技攻关计划(222102310462);河南省高校科技创新团队支持计划(18IRTSTHN025);中原千人计划-中原科技领军人才(204200510020);河南省精神心理疾病临床医学研究中心开放课题(2021-zxkfkt-005)。

摘　　要：目的探讨强迫症患者脑网络节点信息整合与分离的功能改变及其与临床症状的相关性。方法纳入符合入组标准的56例强迫症患者(强迫症组)和56例性别、年龄、受教育年限相匹配的健康对照(对照组)。每个纳入研究的对象都进行静息态全脑功能磁共振成像扫描, 并采用耶鲁-布朗强迫量表(Yale-Brown Obsessive Compulsive Scale, Y-BOCS)评估强迫症组的临床症状。基于图论方法分析和独立样本t检验比较2组间节点功能网络拓扑属性的差异, 并采用偏相关分析探讨差异脑区属性值与临床症状的相关性。结果与对照组相比, 强迫症组左侧颞上回喙部、右侧中央后回干部的全局效率降低, 最短路径长度增大(均为P<0.001, FDR校正);左侧额下回背侧区的局部效率(P=0.002, 未校正)和聚类系数降低(P<0.001, FDR校正);进一步分析发现, 强迫症组左侧颞上回喙部的全局效率值与强迫思维因子分呈正相关(r=0.390, P=0.005), 左侧颞上回喙部的最短路径长度值与强迫思维因子分呈负相关(r=-0.359, P=0.010)。结论强迫症患者额顶叶网络(额下回、中央后回)信息整合与分离功能失调;颞上回喙部信息整合功能异常降低, 且颞上回喙部的全局效率越高、最短路径长度越短, 强迫思维越严重。Objective To explore the functional changes of brain network node information integration and separation in patients with obsessive-compulsive disorder(OCD)and its correlation with clinical symptoms.Methods Fifty-six patients with obsessive-compulsive disorder(OCD group)and fifty-six healthy controls(control group)matched in gender,age and years of education were enrolled.All participants accepted resting-state functional magnetic resonance imaging scans of the whole brain.Yale-Brown Obsessive Compulsive Scale(Y-BOCS)was used to assess patients′clinical symptoms.Based on graph theory and independent-sample t-test,the differences in functional network topological properties of nodes between the two groups were analyzed.Partial correlation analysis was used to discuss the relationship between the values of these properties and clinical symptoms.Results Compared with the control group,the OCD group showed decreased global efficiency and increased shortest path length of the left superior temporal gyrus rostral area and right posterior central gyrus trunk region(both P<0.001,FDR corrected);decreased local efficiency(P=0.002,uncorrected)and clustering coefficient(P<0.001,FDR corrected)of the left inferior frontal gyrus dorsal region.Further analysis showed that the score of the global efficiency of the left superior temporal gyrus rostral area was positively correlated with the score of obsessive thoughts sub-scale(r=0.390,P=0.005).The score of the shortest path length of the left superior temporal gyrus rostral area was negatively correlated with the obsessive thoughts sub-scale(r=-0.359,P=0.010)in the OCD group.Conclusion OCD patients have abnormal information integration and separation functions in the frontoparietal network(inferior frontal gyrus,posterior central gyrus)and abnormal information integration functions in the superior temporal gyrus rostral area.Higher global efficiency and shorter the shortest path length of the superior temporal gyrus rostral area suggest more obsessive thoughts in OCD patients.

关 键 词：强迫性障碍 磁共振成像 脑功能网络 功能整合与分离 

分 类 号：R749.7[医药卫生—神经病学与精神病学]