缺血性卒中侧支血管生成及其治疗性干预的研究进展  

Research progress of collateral angiogenesis and its therapeutic intervention in ischemic stroke

作　　者：王锦坤 储晓娇 章帆 闫文静 覃雪莲 何治[1] Wang Jinkun;Chu Xiaojiao;Zhang Fan;Yan Wenjing;Qin Xuelian;He Zhi(Third-grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,China Three Gorges University,Basic Medical College,China Three Gorges University,Yichang,Hubei 443002,China)

机构地区：[1]三峡大学国家中医药管理局中药药理科研三级实验室三峡大学基础医学院,湖北省宜昌市443002

出　　处：《中国脑血管病杂志》2023年第2期106-111,118,共7页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金面上项目(82073824);湖北省卫生健康委员会联合基金重点项目(WJ2019H526);2018年度天然产物研究与利用湖北省重点实验室(三峡大学)开放基金课题(NPRD-2018001)。

摘　　要：脑侧支血管生成发生在缺血性卒中的各个时期,是指脑缺血区血管内皮细胞经过基膜降解、活化、增殖及迁移等活动,在现存血管的基础上形成微血管网的病理过程。缺血性卒中后,血管网的形成能够有效恢复组织血流灌注,缓解神经功能缺损症状及改善预后。作者从细胞信号传导的角度出发,对缺血性卒中侧支血管生成的机制及其新兴的治疗性干预途径进行了综述。Cerebral collateral angiogenesis occurs in each stage of ischemic stroke.It refers to the pathological process that vascular endothelial cells in the cerebral ischemic area form microvascular network on the basis of existing blood vessels through activities such as basement membrane degradation,activation,proliferation and migration.After ischemic stroke,the formation of vascular network can effectively restore tissue blood perfusion,relieve the symptoms of neurological deficiency and improve the prognosis.From the perspective of cellular signal transduction,the article reviewed the mechanism of collateral angiogenesis and its emerging therapeutic intervention approaches in ischemic stroke.

关 键 词：微RNAS 干细胞 中草药 脑侧支血管生成 信号通路 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]