粪便钙卫蛋白在婴儿非IgE介导的牛奶蛋白过敏中的应用价值  

Application value of fecal calprotectin in infants with non-IgE-mediated milk protein allergy

作　　者：李妍[1] 赵煜[1] LI Yan;ZHAO Yu(Tianjin Children's Hospital,Tianjin 300134,China)

机构地区：[1]天津市儿童医院消化科,天津300134

出　　处：《中国中西医结合儿科学》2023年第1期40-45,共6页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：食物过敏多见于1岁以内的婴儿,以牛奶蛋白过敏引起的肠道症状多见,多为非IgE介导,早期诊断困难,获得耐受的相关机制仍不清楚,诊断及动态监测病情亦无特异性生物学指标,寻找特异性生物学指标帮助早期诊断非常重要。粪便钙卫蛋白具有抗细菌降解的作用,在肠道中不容易被分解,因而能够真实反映肠道的炎症程度,较其他炎症指标更具有肠道特异性。文章就粪便钙卫蛋白在非IgE介导的婴儿牛奶蛋白过敏诊断中的应用及价值作一综述。Food allergy is more common in infants under 1 year old.The intestinal symptoms caused by milk protein allergy(CMPA)are more common,mostly non-IgE-mediated.Early diagnosis is difficult,the relevant mechanism of obtaining tolerance is still unclear,and there are no specific biological indicators for diagnosis and dynamic monitoring of the disease.Therefore,it is very important to find specific biological indicators to help to make early diagnosis.Fecal calprotectin has the effect of anti-bacterial degradation and is not easy to be decomposed in the intestine.Therefore,it can truly reflect the degree of intestinal inflammation and is more intestine-specific than other inflammatory indicators.This paper reviews the application and value of fecal calprotectin in the diagnosis of non-IgE-mediated milk protein allergy in infants.

关 键 词：食物过敏 钙卫蛋白 牛奶蛋白过敏 非IgE介导 婴儿 

分 类 号：R781.67[医药卫生—口腔医学]