创伤后应激障碍多组学生物标志物的研究进展  

Research progress in multi-omics biomarkers involved in post-traumatic stress disorder

作　　者：马燕妮 张程程[1] Ma Yanni;Zhang Chengcheng(Mental Health Center of West China Hospital,Sichuan University,Chengdu 610041,China;West China School of Medicine,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院心理卫生中心,成都610041 [2]四川大学华西临床医学院,成都610041

出　　处：《中华创伤杂志》2023年第1期83-88,共6页Chinese Journal of Trauma

基　　金：中国博士后科学基金(2020M673247);四川省科技厅重点研发项目(2021YFS0248);大学生创新创业训练计划项目(20221174L)。

摘　　要：创伤后应激障碍(PTSD)是暴露于严重应激创伤事件诱发的精神障碍,其反复创伤再体验、回避、负性认知和情绪改变严重降低了患者的生活质量,目前迫切需要进一步明确PTSD的病因和分子机制,以指导PTSD的诊断和治疗。PTSD的潜在发病机制尚不完全清楚,识别相关生物标志物在研究其发生发展中的作用机制至关重要。相比单组学研究,多组学可以多角度系统地阐述生物分子间的相互作用,为理解复杂疾病的发生提供新的手段。因此,笔者从基因组学、转录组学和蛋白质组学等方面对PTSD生物标志物的研究进展进行综述,为今后PTSD的研究及临床治疗提供参考。Post-traumatic stress disorder(PTSD)is a psychiatric illness induced by exposure to severe stress-induced traumatic events.Repeated traumatic re-experience,avoidance,negative cognition and emotional changes seriously reduce the quality of life of PTSD patients.Currently,it is urgent to further clarify the etiology and molecular mechanism of PTSD in order to guide the diagnosis and treatment of PTSD.Considering the underlying pathophysiology is not entirely known,to identify the pertinent biomarkers of PTSD is critical in researching its incidence and progression.In contrast with the single-omics researches,multi-omics studies may methodically expand on biomolecular interactions from a range of angles,creating a new potential to comprehend the development of complicated human illnesses.Therefore,the authors review the research progress in PTSD biomarkers from aspects of genomics,transcriptomics and proteomics,hoping to provide a reference for future research and treatment of PTSD.

关 键 词：应激障碍 创伤后 基因组学 蛋白质组学 生物标志物 

分 类 号：R749.5[医药卫生—神经病学与精神病学]