表皮细胞生长因子及其相关信号通路在角膜损伤修复调控机制的研究进展  

Research progress of epidermal growth factor and its related signaling pathways in the regulation mechanism of corneal injury repair

作　　者：焦一典 牛雨 马铭绅 赵海霞[1] JIAO Yidian;NIU Yu;MA Mingshen;ZHAO Haixia(Myopia Treatment Center,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia Autonomous Region 010050,China)

机构地区：[1]内蒙古医科大学附属医院近视眼治疗中心,内蒙古自治区呼和浩特010050

出　　处：《安徽医药》2023年第3期433-438,共6页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81460090)。

摘　　要：角膜损伤是临床上因为物理、化学、微生物感染、免疫等因素造成的角膜结构、功能异常为主的一系列眼科临床疾病。根据流行病学研究显示,我国不可逆盲病人的40%来自于角膜盲,而各类角膜损伤则是角膜盲的最主要病因。随着相关研究的深入,发现表皮细胞生长因子(epidermal growth factor,EGF)在角膜损伤阶段对伤口的愈合发挥着重要作用,但不同研究表明其在各个通路中存在不同的作用机制,该研究就目前关于EGF在角膜损伤修复过程中的作用通路研究做出综述,旨在为日后角膜损伤修复的临床治疗提供新思路。Corneal injury is a series of ophthalmic clinical diseases in the corneal structure and function abnormality mainly caused by physical, chemical, microbial infection, immunity and other factors. According to epidemiological studies, 40% of irreversible blindness in China is corneal blindness, which is mainly caused by various corneal injuries. The related in-depth researches have found out that epidermal growth factor(EGF) plays an important role in wound healing in the stage of corneal injury, but different studies have shown that it has different mechanisms in respective pathways. This study provides a review of current researches on the role of EGF in corneal injury repair, aiming to provide new ideas for the clinical treatment of corneal injury in the future.

关 键 词：角膜损伤 角膜修复 表皮细胞生长因子 

分 类 号：R772.2[医药卫生—眼科]