局限期小细胞肺癌放射治疗决策的现况调查  

Radiation dose and fractionation regimen for limited stage small cell lung cancer:a survey of current practice patterns of Chinese radiation oncologists

作　　者：徐畅 李萌 陈明[3] 祝淑钗[4] 毕楠 蔡旭伟[6] 袁双虎[7] 曹建忠[8] 胡晓[9] 李建成[10] 周伟 王平 王军[2] 赵路军 刘宁波 Xu Chang;Li Meng;Chen Ming;Zhu Shuchai;Bi Nan;Cai Xuwei;Yuan Shuanghu;Cao Jianzhong;Hu Xiao;Li Jiancheng;Zhou Wei;Wang Ping;Wang Jun;Zhao Lujun;Liu Ningbo(Department of Radiation Oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China;Department of Radiation Oncology,Konggang Branch of Tianjin Cancer Hospital,Tianjin 300308,China;Department of Radiation Oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510055,China;Department of Radiation Oncology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Radiation Oncology,Shanghai Chest Hospital,Shang Hai 200030,China;Department of Radiation Oncology,Shandong Cancer Hospital,Ji'nan 250117,China;Department of Radiation Oncology,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China;Department of Radiation Oncology,Zhejiang Cancer Hospital,Hangzhou 310005,China;Department of Radiation Oncology,Fujian Cancer Hospital,Fuzhou 350014,China;Department of Radiation Oncology,Chongqing University Cancer Hospital,Chongqing 400030,China)

机构地区：[1]天津医科大学肿瘤医院放疗科,国家肿瘤临床医学研究中心天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学研究中心,天津300060 [2]天津市肿瘤医院空港医院放疗科,天津300308 [3]中山大学肿瘤防治中心放疗科,华南肿瘤学国家重点实验室,肿瘤医学省部共建协同创新中心,广州510055 [4]河北医科大学第四医院放疗科,石家庄050011 [5]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京100021 [6]上海市胸科医院放疗科,上海200030 [7]山东省肿瘤医院放疗科,济南250117 [8]山西省肿瘤医院放疗科,太原030013 [9]浙江省肿瘤医院放疗科,杭州310005 [10]福建省肿瘤医院放疗科,福州350014 [11]重庆大学附属肿瘤医院放疗科,重庆400030

出　　处：《中华放射肿瘤学杂志》2023年第2期93-98,共6页Chinese Journal of Radiation Oncology

摘　　要：目的调查中国放射肿瘤医生在局限期小细胞肺癌放疗中分割方案及剂量的选择情况。方法对超过500名放射肿瘤医生进行关于局限期小细胞肺癌放疗推荐及实际中分割方式及相关剂量的选择等问题的问卷调查,获得可用结果216份,并对可用结果进行分析。所有数据通过问卷星软件制作的在线问卷收集,使用SPSS 25.0软件进行数据整理和统计学分析。Fisher精确检验以及χ2检验用于比较分类变量之间的组间差异。结果216名医生中,94.9%推荐早期同步放化疗,69.4%推荐常规分割方案,70.8%推荐60 Gy作为常规分割方案的总剂量,78.7%推荐45 Gy作为超分割方案的总剂量。结论尽管实际工作中对分割方式和剂量的选择存在差异,目前大多数中国放射肿瘤医生在临床实践中更倾向于选择60 Gy常规分割方案。中国临床肿瘤学会(CSCO)、美国国家综合癌症网(NCCN)及中华医学会等的指南或专家共识对日常治疗决策起着重要的指导作用。Objective To investigate the radiation dose and fractionation regimens for limited stage small cell lung cancer(LS-SCLC)in Chinese radiation oncologists.Methods Over 500 radiation oncologists were surveyed through questionnaire for radiation dose and fractionation regimens for LS-SCLC and 216 valid samples were collected for further analysis.All data were collected by online questionnaire designed by WJX software.Data collection and statistical analysis were performed by SPSS 25.0 statistical software.The differences in categorical variables among different groups were analyzed by Chi-square test and Fisher's exact test.Results Among 216 participants,94.9%preferred early concurrent chemoradiotherapy,69.4%recommended conventional fractionation,70.8%preferred a total dose of 60 Gy when delivering conventional radiotherapy and 78.7%recommended 45 Gy when administering hyperfractionated radiotherapy.Conclusions Despite differences in LS-SCLC treatment plans,most of Chinese radiation oncologists prefer to choose 60 Gy conventional fractionated radiotherapy as the main treatment strategy for LS-SCLC patients.Chinese Society of Clinical Oncology(CSCO),National Comprehensive Cancer Network(NCCN)and Chinese Medical Association guidelines or expert consensus play a critical role in guiding treatment decision-making.

关 键 词：小细胞肺癌 局限期 放射疗法 胸部 超分割 大分割 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]