基于磁纳米材料的磁热疗抗肿瘤研究进展  

Research progress of magnetic hyperthermia based on magnetic nanomaterials

作　　者：夏锦丹 吴稚冰 蓝开平 Xia Jindan;Wu Zhibing;Lan Kaiping(The Second Clinical Medical College of Zhejiang Chinese Medicine University,Hangzhou 310053,China;Department of Oncology,Zhejiang Hospital,Hangzhou 310030,China;Department of Oncology,Hangzhou Tonglu Hospital of Traditional Chinese Medicine,Hangzhou 311599,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江医院肿瘤科,杭州310030 [3]杭州市桐庐县中医院肿瘤科,杭州311599

出　　处：《中华放射肿瘤学杂志》2023年第2期164-168,共5页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金(82172679);浙江省医药卫生科技项目(2021KY010);杭州市科技发展项目(20171226Y223)。

摘　　要：肿瘤热疗是继手术、放化疗、靶向治疗等治疗之后又一重要的肿瘤治疗手段。磁热治疗(MH)是一种新兴的热疗方法,因具有无创/微创性、高效性和良好的组织穿透性等优点而受到广泛关注,为恶性肿瘤实现高效、低不良反应精准医疗分子水平治疗提供了新手段,成为目前肿瘤治疗新的研究方向。实现MH需要磁性材料和适宜磁场,其中氧化铁纳米颗粒(IONs)由于其较高的生物相容性和加热能力而被广泛研究为MH剂。本文就磁性纳米氧化铁材料的研究进展及目前基于磁性纳米颗粒的磁性热疗协同抗肿瘤治疗的研究进展进行分析,综述磁热治疗这一前沿技术在肿瘤治疗中的潜在应用。Thermotherapy has become another important tumor treatment after surgery,radiotherapy,chemotherapy,and targeted treatment.Magnetic hyperthermia(MH)is a new type of hyperthermia,which has attracted widespread attention due to its advantages of non-invasiveness/minimal invasiveness,high efficiency and good tissue penetration.It provides a new option for the molecular level treatment of malignant tumors with high efficacy and low toxicity,which has become a new research direction of tumor treatment.Magnetic materials and suitable magnetic fields are needed to realize MH.Iron oxide nanoparticles(IONs)are widely studied as MH agents because of their high biocompatibility and heating ability.In this article,the research progress on magnetic iron oxide nanomaterials and MH combined with antitumor therapy based on magnetic nanoparticles were analyzed,and the potential application of MH in cancer treatment was reviewed.

关 键 词：磁纳米材料 磁热疗法 肿瘤治疗 协同治疗 

分 类 号：R730.5[医药卫生—肿瘤]