肝细胞肝癌患者根治性切除术后复发相关血清标志物的研究进展  

Research progress on the predicting value of serum markers related to postoperative recurrence in patients with hepatocellular carcinoma after curative resection

作　　者：刘瑜 杨文静 郭玮 Yu Liu;Wenjing Yang;Wei Guo(Department of Laboratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Laboratory Medicine,Xiamen Branch,Zhongshan Hospital,Fudan University,Xiamen 361015,China)

机构地区：[1]复旦大学附属中山医院检验科,上海200032 [2]复旦大学附属中山医院厦门医院检验科,厦门361015

出　　处：《中华检验医学杂志》2023年第1期93-97,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81902139);上海市临床重点专科建设项目(shslczdzk03302)。

摘　　要：肝细胞肝癌患者术后5年内复发率高,寻找肝细胞肝癌复发转移的危险因素及预测生物标志物用于评估高复发风险人群至关重要。血清标本容易获得,具有无创、便宜、快速检测的优势。血清标志物可以动态监测患者病情,提示肿瘤复发状态。该文旨在总结肝细胞肝癌患者手术切除后复发相关血清标志物的预测价值,从临床常见血清标志物和液体活检标志物角度出发,为临床医生评估个体患者的复发转移风险提供新思路。Patients with surgically resected hepatocellular carcinoma(HCC)have a high recurrence rate within 5 years after surgery.It is therefore essential to explore the risk factors and predictive biomarkers for HCC recurrence and metastasis to identify high-risk patients for HCC recurrence.Serum specimens are readily available and have the advantage of being non-invasive,inexpensive and rapid to detect.Serum markers can dynamically monitor patients′disease and indicate the status of tumor recurrence.This article summarized the research progress on the predictive value of serum markers associated with recurrence in HCC patients after surgical resection.From the perspectives of common clinical serum markers and liquid biopsy markers,present review aimed to provide some novel ideas for clinicians to assess the risk of HCC recurrence and metastasis in individual patient post-surgical resection of HCC.

关 键 词：肝细胞肝癌 肿瘤复发 血清标志物 

分 类 号：R735.7[医药卫生—肿瘤]