自噬在缺血性脑卒中过程中的作用及其调节机制研究进展  

The role of autophagy and related mechanisms in ischemic brain injury: an update

作　　者：李玥 郑婉晴 潘玲 刘孟茹 周心雨 陈忠[1,2] 张翔南 LI Yue;ZHENG Wan Qing;PAN Ling;LIU MengRu;ZHOU XinYu;CHEN Zhong;ZHANG XiangNan(Institute of Pharmacology and Toxicology,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江大学药理毒理研究所浙江大学药学院,杭州310058 [2]神经药理学与转化研究浙江省重点实验室浙江中医药大学药学院,杭州310053

出　　处：《中国科学：生命科学》2023年第1期19-29,共11页Scientia Sinica(Vitae)

摘　　要：缺血性脑卒中是一种严重的脑血管疾病,具有高发病率、高致残率和高死亡率的特点.自噬是指细胞利用溶酶体降解受损细胞器和大分子物质的过程.缺血后脑内自噬被激活,然而自噬在缺血性脑卒中过程中的作用尚存争议.近年来,越来越多的证据提示自噬通过多种机制减缓了缺血性脑卒中损伤.本文回顾了缺血性脑卒中诱导自噬的主要病理因素,探讨了自噬在缺血脑内的作用及其机制,总结了缺血性脑卒中过程中自噬的调节剂,以期更新对缺血性脑损伤过程中自噬作用及其机制的认识,为相关抗缺血性脑卒中药物的研究提供新的思路.Ischemic stroke is a severe cerebrovascular disease that is associated with high morbidity, disability, and mortality. Ischemia activates neuronal autophagy;however, the contribution of autophagy in ischemic brains remains controversial. Autophagy is an intracellular process by which cells degrade damaged organelles and macromolecules via lysosomal pathways. Emerging evidence suggests that autophagy ameliorates ischemic stroke through a variety of mechanisms. Here, we summarize the pathological events that may trigger autophagy in ischemic brains and discuss how autophagy may impact the process of ischemic stroke. We also review the regulatory mechanisms of autophagy in the process of cerebral ischemia and summarize the bioactive compounds that are known to regulate autophagy in ischemic brains. We aim to update the knowledge regarding autophagy in cerebral ischemia and provide new insights into novel drugs for stroke therapy.

关 键 词：缺血性脑卒中 自噬 线粒体自噬 

分 类 号：R743.3[医药卫生—神经病学与精神病学]