脑梗死后神经细胞替代治疗的前沿进展  

Frontiers of cellular replacement therapy for cerebral infarction

作　　者：龚思琪 邵涵 汤安琪 杨晓燕 蔡秀英[1] 朱珏华 Gong Siqi;Shao Han;Tang Anqi;Yang Xiaoyan;Cai Xiuying;Zhu Juehua(Department of Neurology,First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Neurology,Suzhou High-tech District People's Hospital,Suzhou 215129,China)

机构地区：[1]苏州大学附属第一医院神经内科,苏州215006 [2]苏州高新区人民医院神经内科,苏州215129

出　　处：《中华神经医学杂志》2023年第1期72-76,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金面上项目(82171282);江苏省卫生健康委员会科研项目面上项目(M2020064);苏州市民生科技项目医疗卫生应用基础研究(2020101)。

摘　　要：脑梗死是一种具有高发病率、高致死率、高致残率的疾病,给家庭和社会带来严重负担。神经元作为中枢神经系统的基本结构,死亡后难以再生或增殖,故脑梗死后的神经功能缺损难以完全恢复。伴随干细胞技术和基因重组技术的进步,脑梗死后细胞替代治疗领域的研究有了较大进展,为临床转化应用奠定了基础。本文综述诱导内源性神经再生、外源性干细胞移植、原位体细胞向神经元转分化这三个方面对脑梗死后细胞替代治疗的基础研究进展,以期为脑梗死的治疗提供参考。Cerebral infarction,with high incidence,high mortality,high disability and high recurrence rates,can impose a serious burden on families and society.After cerebral infarction occurrence,neurons,as the fundamental structures of the central nervous system,are unable to renew or multiply after death;hence,full recovery from neurological impairments following cerebral infarction is challenging.With stem cell and genetic recombination advancements,cellular replacement therapy after cerebral infarction progresses,which helps clinical transformation and application.In this paper,the basic researches of cellular replacement therapy after cerebral infarction are reviewed from 3 aspects:endogenous nerve regeneration,exogenous stem cell transplantation,and in situ somatic cell trans-differentiation into neurons,in order to provide references for cerebral infarction treatment。

关 键 词：脑梗死 细胞替代治疗 干细胞 神经再生 

分 类 号：R743.33[医药卫生—神经病学与精神病学]