Blood coagulation factors and platelet response to drug-induced hepatitis and hepatosis in rats  

作　　者：Daria Korolova Viktoriya Gryshchenko Tamara Chernyshenko Oleh Platonov Olha Hornytska Volodymyr Chernyshenko Pavlo Klymenko Yevdokiia Reshetnik Tetyana Platonova 

机构地区：[1]Department of Structure and function of proteins,Palladin Institute of Biochemistry of NAS of Ukraine,Kyiv,Ukraine [2]National University of Life and Environmental Sciences of Ukraine,Kyiv,Ukraine [3]SI“D.F.Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine,”,Kyiv,Ukraine [4]Taras Shevchenko National University of Kyiv,Kyiv,Ukraine

出　　处：《Animal Models and Experimental Medicine》2023年第1期66-73,共8页动物模型与实验医学（英文）

基　　金：National Academy of Sciences of Ukraine research,Grant/Award Number:0119U002512。

摘　　要：Background:Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects.The aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-induced hepatosis and hepatitis in rats.Methods:We modeled diclofenac-induced hepatitis and tetracycline-induced hepa-tosis.Hemostasis response was gauged by measuring fibrinogen,factor X,protein C(PC),and prothrombin in plasma.The decarboxylated form of prothrombin was de-tected by measuring prothrombin index and ecamulin index.Platelet reactivity was studied using aggregometry.Results:Both hepatitis and hepatosis decreased the synthesis of fibrinogen,factor X,and prothrombin.However,protein carboxylation was not disrupted in hepatosis but was much impaired in hepatitis.PC decreased in both models as a consequence of its consumption possibly during inflammatory response.Platelet aggregation rate was lower in hepatosis but higher in hepatitis.Conclusions:Our findings imply the need for a thorough monitoring of the hemostasis system in liver diseases to avoid possible thrombotic complications.Its state indicates the disorder's rate and character.

关 键 词：HEMOSTASIS HEPATITIS hepatosis PLATELETS PROTHROMBIN 

分 类 号：R512.6[医药卫生—内科学]