5-取代-1,6-苯并硫氮杂环-2-辛酮的合成及抑菌活性  

Synthesis and Antimicrobial Activity of 5-substituted-1,6-benzothioazacyclo-2-octanone

作　　者：王紫薇 孙雨佳 张磊 张萍[1] WANG Ziwei;SUN Yujia;ZHANG Lei;ZHANG Ping(College of Chemistry and Materials Science,Hebei Normal University,Hebei Shijiazhuang 050024,China)

机构地区：[1]河北师范大学化学与材料科学学院,河北石家庄050024

出　　处：《河北师范大学学报（自然科学版）》2023年第2期151-157,共7页Journal of Hebei Normal University：Natural Science

基　　金：国家自然科学基金(21801059);河北省自然科学基金(B2017205100)。

摘　　要：以乙酰丙酸乙酯和取代苯甲醛为起始原料,经过Knoevevagel缩合和Michael加成反应合成了一系列未见文献报道的含硫、氮的八元杂环化合物(Ⅱa~f).通过1HNMR,13CNMR,MS和元素分析确证了Ⅱa~f的结构.抑菌活性测试结果显示,氟原子取代的Ⅱb对新生隐球菌具有轻度的抑制作用.A series of sulfur and nitrogen-containing eight-membered heterocyclic compounds(Ⅱa~f) were synthesized from ethyl levulinate and substituted benzaldehyde by Knoeveagel condensation and Michael addition reaction.The structures of Ⅱa~f were characterized by ~1HNMR,13CNMR,MS and elemental analysis.The antimicrobial activity test results showed that compoundⅡb with fluorine had a slight inhibitory effect on Cryptococcus neoformans.

关 键 词：5-取代-1 6-苯并硫氮杂环-2-辛酮 八元杂环化合物 Knoevevagel缩合 抑菌活性 

分 类 号：O622.6[理学—有机化学]