雌激素与结直肠肿瘤关系的研究进展  

Research Progress on Relationship Between Estrogen and Colorectal Neoplasms

作　　者：王莹[1] 杨旭瑶 杨玄 崔月萌 徐声润 常江[1] WANG Ying;YANG Xuyao;YANG Xuan;CUI Yuemeng;XU Shengrun;CHANG Jiang(Department of Gastroenterology,the Second Hospital Affiliated of Kunming Medical University,Kunming,650101)

机构地区：[1]昆明医科大学第二附属医院消化内科,650101

出　　处：《胃肠病学》2022年第1期57-61,共5页Chinese Journal of Gastroenterology

摘　　要：结直肠癌(CRC)是临床最常见的恶性肿瘤之一,其发病率和死亡率仍呈上升趋势,结直肠肿瘤性息肉是CRC的主要癌前病变。男性结直肠肿瘤发病率和死亡率均高于女性,且外源性雌激素补充可降低女性CRC的发病率,提示雌激素在肠道肿瘤的发生、发展中可能起到保护作用。本文就雌激素与结直肠肿瘤关系的研究进展作一综述。Colorectal cancer(CRC)is one of the most common clinical malignancies,its morbidity and mortality are still on the rise.Colorectal tumorous polyp is the main precancerous lesion of CRC.The morbidity and mortality of colorectal neoplasms in men are higher than those in women,and exogenous estrogen supplementation can reduce the incidence of CRC in women,which suggests that estrogen may play a protective role in the occurrence and development of colorectal neoplasms.This article reviewed the research progress on the relationship between estrogen and colorectal neoplasms.

关 键 词：结直肠肿瘤 雌激素类 受体 雌激素 

分 类 号：R735.34[医药卫生—肿瘤]