异种蛋白诱导法建立IgA肾病动物模型研究进展  

Research progress on establishment of animal model of IgA nephropathy by heterogeneous protein induction

作　　者：杨文 宋丹 宋纯东[3] 郭婷[3] 段凤阳[3] 王宁丽 张博[3] 杨濛[3] YANG Wen;SONG Dan;SONG Chundong;GUO Ting;DUAN Fengyang;WANG Ningli;ZHANG Bo;YANG Meng(College of Pediatrics,Medicine Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Medicine Henan University of Traditional Chinese Medicine,Zhengzhou 450046;Department of Pediatrics,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450003)

机构地区：[1]河南中医药大学儿科医学院,郑州450046 [2]河南中医药大学,郑州450046 [3]河南中医药大学第一附属医院儿科,郑州450003

出　　处：《中国比较医学杂志》2022年第12期82-87,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金项目(82074493);河南省中医药学科领军人才项目(豫卫中医函(2021)8号);河南省卫生健康委员会中医药青苗人才(豫卫中医函[2021]16号);河南省中医管理局国家中医临床研究基地科研专项重点课题(2018JDZX119);河南省中医药管理局国家中医临床研究基地科研专项普通课题(2018JDZX017)。

摘　　要：本文总结了目前常见的异种蛋白诱导法建立IgA肾病(IgAN)动物模型的各种造模方法,指出其各自的特色与不足及各模型间的异同点,并提出了模型改良思路,以期为建立更加安全、稳定、成功率高、可重复性强、且与人类更为相似的IgAN动物模型提供思路。This paper summarizes various methods for establishing animal models of IgA nephropathy(IgAN)by immune induction.The models’respective characteristics and shortcomings and the similarities and differences between them are discussed.We propose that improvements to models are needed and provide ideas for establishing safer,more stable animal models with a higher success rate and robust repeatability that more closely mimic human IgAN.

关 键 词：IGAN 动物模型 异种蛋白诱导 研究进展 

分 类 号：R-33[医药卫生]