非编码RNA在骨性关节炎中对软骨细胞和胞外基质影响的研究进展  

Research progress on the effect of non-coding RNA on chondrocytes and the extracellular matrix in osteoarthritis

作　　者：王世琦 岳亮[2] 谢文鹏 蔡余力 WANG Shiqi;YUE Liang;XIE Wenpeng;CAI Yuli(the First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Orthopedics,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学附属医院骨科,济南250014

出　　处：《中国比较医学杂志》2022年第12期88-94,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金青年项目(82104897);山东省中医药科技发展计划项目(2019-0084);山东省自然科学基金青年项目(ZR2020QH312)。

摘　　要：骨性关节炎(osteoarthritis,OA)是致残率最高的慢性疾病,由于肥胖率增加和老龄化的到来,OA对人们的生活和社会资源产生越来越大的负面影响。随着高通量技术的发展,非编码RNA的研究逐渐成为OA领域的热点,近来的研究表明软骨细胞凋亡及细胞外基质的降解是OA主要的病理基础,非编码RNA与软骨细胞存在密切联系,但其分子机制尚未完全阐明。本文就非编码RNA对软骨细胞和胞外基质的影响做一综述,以期进一步了解软骨退变的机制,为OA的早期诊疗提供新思路。Osteoarthritis(OA)is a chronic disease with a high disability rate.With the increase in the obesity rate and an aging patient population,OA is having more and more negative impacts on peoples’lives and social resources.With the development of high-throughput technology,the study of non-coding RNA has gradually become a hot spot in the field of OA.Recent studies have shown that chondrocyte apoptosis and extracellular matrix degradation are the main pathological bases of OA.Non-coding RNA is closely related to chondrocytes,but the molecular mechanism has not been fully clarified.This article reviews the effects of non-coding RNA on chondrocytes and the extracellular matrix to further understand the mechanisms of cartilage degeneration and provide new ideas for the early diagnosis and treatment of OA.

关 键 词：骨性关节炎 非编码RNA 微小RNA 长链非编码RNA 环状RNA 

分 类 号：R-33[医药卫生]