某医院女性体检者人乳头瘤病毒感染状况及影响因素分析  

Analysis of human papillomavirus infection status and influencing factors among female health examiners in a hospital

作　　者：杜彦丹[1] 孙辉[1] 包春喜 郑海军 李春雨 董占柱 张仕华[1] Du Yandan;Sun Hui;Bao Chunxi;Zheng Haijun;Li Chunyu;Dong Zhanzhu;Zhang Shihua(Department of Clnical Laboratory,Inner Mongolia Forestry General Hospital/the Second Clinical Medicine College of Inner Mongolia University for Nationalities,Hulun Buir 022150,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古林业总医院/内蒙古民族大学第二临床医学院检验科,内蒙古自治区牙克石022150

出　　处：《实用检验医师杂志》2022年第4期382-385,共4页Chinese Journal of Clinical Pathologist

基　　金：内蒙古民族大学国家基金培育项目(NMDGP17108)。

摘　　要：目的 探讨某医院女性体检者人乳头瘤病毒(HPV)感染现状及基因分型,分析HPV感染的影响因素,为呼伦贝尔地区女性宫颈癌的预防提供理论依据。方法 选择2021年1月—2022年2月在内蒙古林业总医院(内蒙古民族大学第二临床医学院)进行HPV检查的783名女性体检者作为研究对象。分析不同年龄段受检者的感染类型分布,采用单因素分析和多因素Logistic分析考察HPV感染的危险因素。结果 在783例研究对象中检出HPV阳性93例,总阳性率为11.88%,其中单一型感染77例,感染率为9.89%。高危型感染以HPV52、HPV58、HPV68、HPV16亚型为主,低危型感染以HPV42、HPV6、HPV44亚型为主,其中HPV52型感染率最高。在不同年龄段的受检者中,>55岁人群的HPV感染率最高,为25.00%;吸烟[优势比(OR)为2.547,95%可信区间(95%CI)为1.295~4.673]、性伴侣人数≥2(OR值为2.411,95%CI为1.204~4.826)均为感染HPV的危险因素(均P<0.05),每天清洗外阴为HPV感染的保护性因素(OR值为2.885,95%CI为1.743~4.777)。结论 该地区体检者HPV感染型别中,高危型感染以HPV52型为主,低危型感染以HPV42型为主,>55岁是HPV感染的高峰年龄段;吸烟、性伴侣人数≥2均为HPV感染的危险因素,应有针对性地采取预防措施。Objective To investigate the current status and genotype of human papillomavirus(HPV) infection among female health examiners in a hospital, and to analyze the influencing factors of HPV infection, so as to provide a theoretical basis for the prevention of cervical cancer in Hulun Buir area. Methods The 783 cases of female examiners undergoing HPV examination from January 2021 to February 2022 in Inner Mongolia Forestry General Hospital(the Second Clinical Medical School of Inner Mongolia University for Nationalities) were selected as research objects. The distribution of infection among subjects at different ages was analyzed, and the risk factors of HPV infection was investigated by single factor analysis and multivariate Logistic analysis. Results Among the 783 examiners, 93 cases were positive for HPV, with a total positive rate of 11.88%. Among them, 77 cases were single type infection, with the infection rate of 9.89%. HPV52, HPV58, HPV68 and HPV16 subtypes were the main high-risk types of infection, while HPV42, HPV6 and HPV44 subtypes were the main low-risk types, of which HPV52 had the highest infection rate. Among different age groups, the highest rate of HPV infection was 25.00% in women > 55 years old. Smoking [odds ratio(OR) was 2.547, 95% confidence interval(95%CI) was 1.295-4.673] and number of sexual partners≥2(OR value was 2.411, 95%CI was 1.204-4.826) were risk factors for HPV infection(both P < 0.05), and washing vulva everyday(OR value was 2.885, 95%CI was 1.743-4.777) was a protective factor for HPV infection. Conclusions The HPV infection type of the examiners in this area is mainly type HPV52 in high risk and type HPV42 in low risk. The peak age of HPV infection is > 55 years old. Smoking and ≥two sexual partners are risk factors for HPV infection, and targeted preventive measures should be taken.

关 键 词：人乳头瘤病毒 感染型别 宫颈癌 影响因素 

分 类 号：R737.33[医药卫生—肿瘤]