PPI-clarithromycin-metronidazole三聯療法一線根除幽門螺桿菌的回顧性分析  

A retrospective study on the eradication rate of PPI-clarithromycin-metronidazole triple therapy as first-line treatment for H.pylori infection

作　　者：張進文 王文棟 朱雪茵 ZHANG Jin Wen;WANG Wen Dong;ZHU Xue Yin(Department of Gastroenterology,Kiang Wu Hospital,Macao,China)

机构地区：[1]澳門鏡湖醫院消化内科,中國

出　　处：《镜湖医学》2019年第2期68-70,38,共4页MEDICAL JOURNAL OF KIANG WU

摘　　要：目的因抗生素耐藥比例增加,PPI-clarithromycin-metronidazole三聯療法在本澳一線治療幽門螺桿菌的根除率需進一步研究。方法回顧性分析2012年7月1日~2017年6月3日本院含metronidazole三聯療法一線根治幽門螺桿菌並複查的成人連續患者,分別紀錄其一般情況、藥敏情況、根除方案及根除療效。結果共32例患者納入研究,16例根除成功,16例根除失敗,總體根除率為50.0%。不同性別、年齡、治療年份、有無青霉素過敏、不同metronidazole劑量或治療療程亞組間差異無統計學意義。結論本組患者中含metronidazole的三聯方案根除率僅為50%,於本澳地區根除率低。Objective To assess the eradication rate of PPI-clarithromycin-metronidazole triple therapy as first-line treatment for H.pylori infection in Macao region.Methods H.pylori infected patients who received PPI-clarithromycin-metronidazole triple therapyand confirmed the eradiation between July,01,2012 and June,30,2017 in Kiang Wu Hospital were recorded.Their clinical characters were analyzed.Results A total of 32 patients were recruited.H.pylori eradication was achieved in 16 of 32(50.0%)patients.No significant differences were found between different gender,age,time,penicillin allergy history,metronidazole dosage or treatment duration.Conclusion PPI-clarithromycin-metronidazole triple therapy showed low eradication rate.

关 键 词：PPI-clarithromycin-metronidazole三聯療法 一線治療 幽門螺桿菌 根除率 

分 类 号：R57[医药卫生—消化系统]