miUNA在骨骼生长发育和骨性关节炎中的作用  

Role of miRNA in skeletal development and osteoarthritis

作　　者：郝耀 陈丽 韩永斌[1] 高宏[1] 韩树峰[1] Hao Yao;Chen Li;Han Yongbin;Gao Hong;Han Shufeng(Department of Orthopaedics,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Medical Service,Shanxi Bethune Hospital,Taiyuan 030006,China)

机构地区：[1]山西医科大学第一医院骨科,太原030001 [2]山西白求恩医院医务处,太原030006

出　　处：《中华损伤与修复杂志（电子版）》2023年第1期73-77,共5页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：山西省应用基础研究计划资助项目(201901D211481);山西省留学回国人员科技活动择优资助项目(20200037);山西省回国留学人员科研资助项目(2022-189)。

摘　　要：miRNA是一类调节基因表达的非编码小RNA(大约21核苷酸大小),在软骨内成骨、维持关节软骨内稳态以及骨性关节炎的疾病进程中起着重要的调节作用。对软骨细胞特定的miRNA以及其靶基因的研究对理解软骨内成骨(如骨骼发育)以及软骨相关疾病(如骨性关节炎)的发病机制提供了新的思路。随着越来越多的miRNA在骨性关节炎进展中的作用得到验证,运用miRNA治疗骨性关节炎逐渐成为转化医学研究的热点。本文着重阐述软骨细胞特定miRNA在骨骼发育和骨性关节炎中的作用,进一步阐明运用miRNA治疗骨性关节炎的潜力。miRNA are a small non-coding RNA(about 21 nucleotides in size)that regulate gene expression and play an important regulatory role in endochondral osteogenesis,maintenance of articular cartilage homeostasis and the disease progression of osteoarthritis.The study of chondrocyte specific miRNA and their target genes provides new insights into the pathogenesis of endochondral osteogenesis(such as skeletal development)and cartilage related diseases like osteoarthritis.As more and more miRNA′s role in the progression of osteoarthritis has been verified,the application of miRNA in the treatment of osteoarthritis has gradually become a focus of translational medicine research.This article focus on the role of chondrocytes-specific miRNA in bone development and osteoarthritis,and further elucidates the potential of miRNA for the treatment of osteoarthritis.

关 键 词：微RNAS 骨关节炎 基因 软骨内成骨 软骨内稳态 

分 类 号：R73[医药卫生—肿瘤]