成纤维细胞在增生性瘢痕形成中的作用及调控因素  

Role and regulatory factors of fibroblasts in hypertrophic scar formation

作　　者：王一淼 何培杰 Wang Yimiao;He Peijie(Department of ENT,Eye&ENT Hospital of Fudan University,Shanghai 200031,China)

机构地区：[1]复旦大学附属眼耳鼻喉科医院耳鼻咽喉科,上海200031

出　　处：《中华损伤与修复杂志（电子版）》2023年第1期78-85,共8页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

摘　　要：增生性瘢痕是细胞外基质(ECM)成分过度沉积导致的结果,对患者的生活质量产生明显影响。不论是在正常的伤口愈合还是增生性瘢痕形成的过程中,成纤维细胞都发挥着不可或缺的作用。成纤维细胞在促进瘢痕形成的过程中受到多种细胞生长因子的调节,这些细胞生长因子通过不同的信号通路发挥作用。阐明这些细胞生长因子和信号通路与增生性瘢痕的关系将有助于新型药物的研发以及增生性瘢痕的治疗。本文对增生性瘢痕形成机制进行了总结,明确了成纤维细胞的功能与其分泌的生长因子在增生性瘢痕形成中的作用,同时简要总结了与瘢痕形成相关生长因子涉及到的信号通路,提供了增生性瘢痕治疗的新方向。Hypertrophic scars are the result of excessive deposition of extracellular matrix(ECM)components,which have a significant impact on the patient′s quality of life.Fibroblasts play an integral role in both normal wound healing and hypertrophic scarring.Fibroblasts are regulated by a variety of cell growth factors in the process of promoting scarring which play their roles through different signaling pathways.Elucidating the relationship between the above factors or pathways and hypertrophic scar may contribute to the development of new drugs and the treatment of hypertrophic scar.This article summarizes the mechanism of hypertrophic scarring,clarifies the function of fibroblasts and the role of growth factors secreted by them in hypertrophic scarring,and briefly summarizes the signaling pathways involved in scarring-related growth factors,providing a new direction for the treatment of hypertrophic scars.

关 键 词：成纤维细胞 瘢痕 细胞外基质 生长因子 信号通路 

分 类 号：R73[医药卫生—肿瘤]