多发性硬化认知功能障碍研究进展  

Cognitive impairments in patients with multiple sclerosis

作　　者：刘煊 曾译萱 蔡婧婧 徐格林 任力杰[2] LIU Xuan;ZENG Yixuan;CAI Jingjing;XU Gelin;REN Lijie(Department of Neurology,The First Affiliated Hospital of Shenzhen University,Shenzhen 51800,China)

机构地区：[1]深圳大学医学部,深圳518000 [2]深圳市第二人民医院神经内科

出　　处：《中国神经精神疾病杂志》2023年第1期60-64,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：深圳市神经系统疾病医防融合项目(编号:6099027)。

摘　　要：认知功能障碍是多发性硬化(multiple sclerosis,MS)的常见非运动症状,主要表现在信息处理、记忆力、注意力、执行力和视觉空间能力等多个认知域受损;目前尚未形成统一的针对MS认知功能障碍的诊断标准和神经心理学检测方法;MS认知功能障碍的影响因素包括人口学因素、疾病相关因素、共病及生活方式等;影像学上主要表现为局灶性白质损伤、皮质和深部灰质萎缩;疾病修正治疗和认知康复治疗对认知功能的改善有积极影响。神经科医师应注重MS认知功能障碍的早期评估和干预,以改善患者生活质量。Cognitive impairment is a common non-motor symptom of multiple sclerosis(MS).It disturbs vital cognitive domains such as speed of information processing,memory,attention,executive functions and visual perceptual functions.At present,there are no unified standards and neuropsychological detection methods for MS cognitive impairment.Influencing factors include demographic factors,disease-related factors,comorbidities,lifestyle factors,etc.Magnetic resonance imaging shows focal white matter lesions,cortical and deep gray matter atrophy.Disease-modifying treatment and cognitive rehabilitation have positive effects on cognitive function.Neurologists should pay attention to early assessment and intervention of MS cognitive impairment to improve patients'quality of life.

关 键 词：多发性硬化 认知功能障碍 神经心理学测验 影响因素 磁共振成像 疾病修正治疗 综述 

分 类 号：R749.1[医药卫生—神经病学与精神病学]