我国一般人群原发性胆汁性胆管炎患病率及其影响因素的系统综述  

Prevalence of primary biliary cholangitis in the Chinese general population and its influencing factors:A systematic review

作　　者：刘智成 王资隆 郑佳睿 谢艳迪[1] 宋广军[1] 封波[1] LIU Zhicheng;WANG Zilong;ZHENG Jiarui;XIE Yandi;SONG Guangjun;FENG Bo(Department of Hepatology,Peking University People’s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院肝病科,北京100044

出　　处：《临床肝胆病杂志》2023年第2期325-332,共8页Journal of Clinical Hepatology

摘　　要：目的 系统回顾原发性胆汁性胆管炎(PBC)流行病学研究,了解中国一般人群PBC的患病率及其影响因素。方法 检索PubMed、Embase、The Cochrane Library、CNKI和万方自建库至2022年3月31日发表的有关我国PBC流行病学研究文献。2位研究者独立筛选文献、提取资料,然后进行分析。结果 共纳入9篇研究文献。AMA阳性率及PBC患病率分别为1 049.05/10万(范围159.65/10万~2 287.40/10万)和123.68/10万(范围42.70/10万~276.59/10万)。AMA阳性率在男女中分别为636.51/10万(范围52.55/10万~1 164.33/10万)和1 265.47/10万(范围225.23/10万~1 704.93/10万),AMA患病率男女比为1∶1.99。PBC患病率在男女中分别为40.81/10万(范围23.54/10万~75.10/10万)和148.71/10万(范围77.36/10万~214.91/10万),PBC患病率男女比为1∶3.64。结论 不同研究我国一般人群AMA阳性率及PBC患病率差别较大,其主要受年龄、性别及地区影响。从整体看,AMA阳性率及PBC患病率随年龄增大而增大,年龄≥50岁AMA阳性率明显高于年龄<50岁。AMA阳性率远高于PBC患病率。AMA阳性人群和PBC患者女性明显多于男性,性别对AMA的影响小于其对PBC的影响。Objective To systematically review the epidemiological studies on primary biliary cholangitis(PBC),and to investigate the prevalence rate of PBC in the Chinese general population and its influencing factors.Methods PubMed,Embase,The Cochrane Library,CNKI,and Wanfang Data were searched for articles on the epidemiology of PBC in China published up to 31th March 2022.Two researchers independently performed screening and data extraction,and then related analyses were performed.Results A total of 9 articles were included.The positive rate of AMA was 1 049.05/100 000(ranging from 159.65/100 000 to 2287.40/100 000),and the prevalence rate of PBC was 123.68/100 000(ranging from 42.70/100 000 to 276.59/100 000).The positive rate of AMA was 636.51/100 000(ranging from 52.55/100 000 to 1 164.33/100 000) in men and 1 265.47/100 000(ranging from 225.23/100 000 to 1 704.93/100 000) in women,with a male/female ratio of 1∶1.99 for the prevalence rate of AMA.The prevalence rate of PBC was 40.81/100 000(ranging from 23.54/100 000 to 75.10/100 000) in men and 148.71/100 000(ranging from 77.36/100 000 to 214.91/100 000) in women,with a male/female ratio of 1∶3.64 for the prevalence rate of PBC.Conclusion Different studies show great differences in the positive rate of AMA and the prevalence rate of PBC in the Chinese general population,which is mainly affected by sex,age,and region.The positive rate of AMA and the prevalence rate of PBC increase with age,and the patients aged ≥50 years have a significantly higher positive rate of AMA than those aged <50 years.The positive rate of AMA is significantly higher than the prevalence rate of PBC.There are significantly more women than men in the AMA-positive population and the PBC patients,and the influence of sex on AMA is lower than that on PBC.

关 键 词：原发性胆汁性胆管炎 流行病学 患病率 

分 类 号：R575.7[医药卫生—消化系统]