超声内镜对胆总管泥沙样结石的诊断价值  

Value of endoscopic ultrasonography in the diagnosis of muddy stones of the common bile duct

作　　者：王雪彩 张启芳[2] 李晓燕[2] 潘炜 杨良庆[2] 张海莲[2] WANG Xuecai;ZHANG Qifang;LI Xiaoyan;PAN Wei;YANG Liangqing;ZHANG Hailian(Graduate School of Guilin Medical University,Guilin,Guangxi 541000,China;Department of Gastroenterology,Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin,Guangxi 541002,China)

机构地区：[1]桂林医学院研究生学院,广西桂林541000 [2]广西壮族自治区南溪山医院消化内科,广西桂林541002

出　　处：《临床肝胆病杂志》2023年第2期370-375,共6页Journal of Clinical Hepatology

基　　金：广西自然科学基金(2015GXNSFAA139222);广西壮族自治区卫生健康委计划课题(Z20200686)。

摘　　要：目的 通过比较超声内镜(EUS)及CT、腹部超声(TUS)对胆总管泥沙样结石的诊断能力,探讨EUS能否成为诊断性内镜逆行胰胆管造影(ERCP)的替代方法。方法 选取2019年7月—2021年12月于广西壮族自治区南溪山医院就诊的53例疑似胆总管泥沙样结石的患者进行前瞻性研究,所有患者在行ERCP前均接受EUS、TUS和CT检查;以ERCP检查并行十二指肠乳头括约肌切开术(EST)取出胆总管泥沙样结石作为诊断胆总管泥沙样结石的金标准,将EUS、TUS和CT对胆总管泥沙样结石显示情况进行比较,计数资料组间比较采用χ~2检验或Fisher精确概率法。结果 53例患者中,EUS、TUS和CT检出胆总管泥沙样结石的阳性率分别为88.68%、50.94%和62.26%;在经ERCP下EST所证实的的阳性结果中,其中EUS检出胆总管泥沙样结石的敏感度、特异度和准确度分别为93.75%、60.00%和90.57%;TUS分别为56.25%、100.00%和60.38%;而CT为66.67%、80.00%和67.92%。EUS检出胆总管泥沙样结石的准确性与CT比较,差异有统计学意义(χ~2=8.26,P=0.004),EUS与TUS的诊断准确性比较,差异有统计学意义(χ~2=13.05,P<0.001)。结论 在胆总管泥沙样结石的诊断上,EUS比TUS和CT的检出更准确,对于TUS、CT未能发现病变而临床怀疑为胆总管泥沙样结石时,推荐进行EUS检查,以便明确诊断,而不是首选ERCP检查,为此可以减少相关成本和由此带来的并发症。Objective To investigate whether endoscopic ultrasonography(EUS) can be an alternative method for diagnostic endoscopic retrograde cholangiopancreatography(ERCP) by comparing the ability of EUS versus CT and transabdominal ultrasonography(TUS) in the diagnosis of muddy stones of the common bile duct.Methods A prospective study was conducted for 53 patients suspected of muddy stones of the common bile duct who attended Nanxishan Hospital of Guangxi Zhuang Autonomous Region from July 2019 to December 2021,and all patients underwent EUS,TUS,and CT before ERCP.With ERCP and endoscopic sphincterotomy(EST) for removing muddy stones of the common bile duct as the gold standard for the diagnosis of muddy stones of the common bile duct,EUS,TUS,and CT were compared in terms of their ability to display the muddy stones of the common bile duct.The chi-square test or the Fisher’s exact test was used for comparison of categorical data between groups.Results In the 53 patients,EUS,TUS,and CT had a positive rate of 88.68%,50.94%,and 62.26%,respectively,in detecting muddy stones of the common bile duct.As for the positive results confirmed by EST under ERCP,EUS had a sensitivity of 93.75%,a specificity of 60.00%,and an accuracy of 90.57% in detecting muddy stones of the common bile duct,while TUS had a sensitivity of 56.25%,a specificity of 100.00%,and an accuracy of 60.38% and CT had a sensitivity of 66.67%,a specificity of 80.00%,and an accuracy of 67.92%.There was a significant difference between EUS and CT in the accuracy in detecting muddy stones of the common bile duct(χ~2=8.26,P=0.004),and there was also a significant difference in diagnostic accuracy between EUS and TUS(χ~2=13.05,P<0.001).Conclusion EUS is more accurate than TUS and CT in the diagnosis of muddy stones of the common bile duct,and instead of ERCP,EUS is thus recommended for suspected muddy stones of the common bile duct when TUS and CT fail to identify the lesions in clinical practice,so as to make a confirmed diagnosis and reduce related costs and comp

关 键 词：胆总管结石病 腔内超声检查 胰胆管造影术 内窥镜逆行 诊断 

分 类 号：R575.7[医药卫生—消化系统]