硫酸软骨素应用于骨修复材料中的研究进展  

Progress of research on application of chondroitin sulfate in osteogenic repair materials

作　　者：张茜[1] 王畅 梁琛 曲星源 刘悦 闫宝君 王雷[1] ZHANG Qian;WANG Chang;LIANG Chen;QU Xingyuan;LIU Yue;YAN Baojun;WANG Lei(Department of Periodontics,Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院牙周科,吉林长春130021 [2]吉林省延边州安图县人民医院口腔科,吉林延边133600

出　　处：《口腔医学》2023年第1期88-91,共4页Stomatology

基　　金：吉林省科技发展计划项目(20200201389JC);吉林省教育厅科学技术研究项目(JJKH20211218KJ)。

摘　　要：硫酸软骨素是细胞外基质(extracellular matrix,ECM)的重要组成部分。近年来,硫酸软骨素被证实在生物医学应用中具有潜在的功效,已被广泛应用于骨再生和骨修复治疗,尤其是在颅面修复和牙科医学领域。研究表明,硫酸软骨素衍生物及硫酸软骨素复合支架在促进成骨和生物矿化方面显示出极大的潜力。但是,由于硫酸软骨素种类繁多,应用形式广,对硫酸软骨素成骨修复机制的研究仍然存在不足。该文就硫酸软骨素的生物学特性、成骨修复作用、不同生物材料设计中的应用及未来展望进行阐述。Chondroitin sulfate is an important component of extracellular matrix(ECM)in animal and human body.In recent years,chondroitin sulfate has been proven to have potential efficacy in biomedical application and has been widely used in bone regeneration and osteogenesis,especially in craniofacial reconstruction and dental medicine.Research shows that chondroitin sulfate derivatives and chondroitin sulfate composite scaffolds have great potential in promoting osteogenesis and biomineralization.However,due to the variety of chondroitin sulfate and various application forms,study on its mechanism of osteogenic repair is still insufficient.In this paper,biological characteristics,bone regeneration and osteogenesis of chondroitin sulfate,its application in different biomaterial design and future prospect are discussed.

关 键 词：硫酸软骨素 骨再生 骨修复 骨组织工程 

分 类 号：R783.1[医药卫生—口腔医学]