补中益气汤对老年晚期消化系统恶性肿瘤骨髓抑制及生活质量的影响  

Effect of Buzhong Yiqi Decoction on bone marrow suppression and quality of life in elderly patients with advanced digestive system malignant tumors

作　　者：朱明辉 曹静[1] 周玺[1] 李雁飞[1] ZHU Minghui;CAO Jing;ZHOU Xi;LI Yanfei(Department of Elderly Digestion,Jiangsu Provincial People’s Hospital,Jiangsu Province,Nanjing 210029,China)

机构地区：[1]江苏省人民医院老年消化科,江苏南京210029

出　　处：《中国医药导报》2023年第5期90-93,97,共5页China Medical Herald

基　　金：江苏省自然科学基金资助项目(BK20200265)。

摘　　要：目的探究补中益气汤对老年晚期消化系统恶性肿瘤骨髓抑制及生活质量的影响。方法选取2019年1月至2022年4月江苏省人民医院接诊的83例老年晚期消化系统恶性肿瘤患者,采用随机数字表法将其分为对照组(41例,XELOX化疗)和观察组(42例,XELOX化疗+补中益气汤)。统计并比较两组化疗后4周的临床疗效及化疗后1周的骨髓抑制情况,统计并比较两组化疗前及化疗后1周的生活质量和免疫水平。记录化疗期间的不良反应发生情况。结果化疗后4周,观察组疗效优于对照组,差异有统计学意义(P<0.05)。化疗后1周,观察组骨髓抑制率Ⅱ级及以上的发生率低于对照组,差异有统计学意义(P<0.05)。化疗后1周,对照组卡氏功能状态(KPS)评分低于本组治疗前,观察组KPS评分高于本组治疗前,两组免疫球蛋白(Ig)M、IgG、IgA水平均高于治疗前,且观察组KPS评分、IgM、IgG、IgA均高于对照组,差异有统计学意义(P<0.05)。两组治疗期间恶心呕吐、腹泻、脱发发生率比较,差异无统计学意(P>0.05)。结论补中益气汤可以提高老年晚期消化系统恶性肿瘤患者的临床疗效,降低骨髓抑制程度,极大地改善了患者的生活质量与免疫能力,可以在临床治疗中推广使用。Objective To explore the effect of Buzhong Yiqi Decoction on bone marrow suppression and quality of life in elderly patients with advanced digestive system malignant tumors.Methods Eighty-three elderly patients with advanced digestive system malignant tumor admitted to Jiangsu Provincial People’s Hospital from January 2019 to April 2022 were selected and divided into control group(41 cases,XELOX chemotherapy)and observation group(42 cases,XELOX chemotherapy+Buzhong Yiqi Decoction)by random number table method.The clinical efficacy of four weeks after chemotherapy and the myelosuppression of one week after chemotherapy were analyzed and compared between the two groups.The quality of life and immune level before and one week after chemotherapy were analyzed and compared between the two groups.The occurrence of adverse reactions during chemotherapy was recorded.Results At four weeks after chemotherapy,the curative effect of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).One week after chemotherapy,the incidence of gradeⅡand above myelosuppression rate in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).One week after chemotherapy,the Kanofsky performance status(KPS)score of control group was lower than that of control group before treatment,the KPS score of observation group was higher than that of observation group before treatment,and the levels of immunoglobulin(Ig)M,IgG,and IgA in both groups were higher than those before treatment,KPS score,IgM,IgG,and IgA in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidence of nausea,vomiting,diarrhea,and alopecia between the two groups(P>0.05).Conclusion Buzhong Yiqi Decoction can improve the clinical efficacy of elderly patients with advanced digestive system malignant tumors,reduce the degree of bone marrow supp

关 键 词：补中益气汤 消化系统恶性肿瘤 骨髓抑制 生活质量 免疫水平 

分 类 号：R735[医药卫生—肿瘤]