基于数据挖掘探究王坤根教授治疗胃癌前病变用药规律  

Explore the drug law of professor Wang Kungen in the treatment of gastric precancerous lesions based on data mining

作　　者：蔡利军[1] 施易辉 何慧 芮晓薇 毛相荧 冯桐妃 王坤根[1] CAI Lijun;SHI Yihui;HE Hui;RUI Xiaowei;MAO Xiangying;FENG Tongfei;WANG Kungen(The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Chinese Medicine,Zhejiang Province,Hangzhou 310003,China)

机构地区：[1]浙江中医药大学附属第一医院浙江省中医院,浙江杭州310003

出　　处：《中国医药导报》2023年第5期150-154,共5页China Medical Herald

基　　金：浙江省中医药科学研究基金项目(2021ZB088);浙江省中青年临床名中医项目(浙中医药〔2021〕22号)。

摘　　要：目的基于中医传承辅助平台探究王坤根教授治疗胃癌前病变用药规律。方法收集浙江省中医院2016年12月至2020年12月就诊于王坤根教授门诊且通过胃镜病理报告诊断为胃癌前病变的病例。建立方剂数据库,通过中医传承辅助平台分别从频数、关联规则、复杂系统熵聚类分析等处理方法得出结论。结果共获得门诊病例130例,获取首诊方剂130首,涉及中药132种,其中频次>20次的中药有25味,用药以苦寒为主,多归脾、胃、肝经。从关联规则获得核心组方为柴胡、郁金、半夏、陈皮、茯苓、蒲公英、黄连,从熵聚类共获得新处方4个。结论王坤根教授治疗胃癌前病变核心药物为柴胡、郁金、半夏、陈皮、茯苓、蒲公英、黄连,主要以疏肝清热、理气和胃、燥湿化痰为治则治疗胃癌前病变。Objective To explore professor Wang Kungen’s prescription rules for the treatment of gastric precancerous lesions,based on the traditional Chinese medicine inheritance assistant platform.Methods Cases diagnosed as gastric precancerous lesions through gastroscopic pathology reports were collected from professor Wang Kungen’s clinic in Zhejiang Provincial Hospital of Chinese Medicine from December 2016 to December 2020.Prescription database was established,and conclusions were drawn from frequency analysis,association rules,complex system entropy clustering analysis,and other processing methods through tradition Chinese medicine inheritance assistance platform.Results A total of 130 outpatient cases were obtained,and 130 first-diagnosed prescriptions were obtained,involving 132 kinds of Chinese medicines.Among them,25 Chinese medicines with a frequency of>20 times were obtained,drugs to bitter cold,mainly return to the spleen,stomach,liver meridian.The core prescriptions were Chinese thorowax root,turmeric root tuber,pinellia tuber,dried tangerine peel,indian bread,dandelion,golden thread,and four new prescriptions were obtained from entropy clustering.Conclusion The core drugs of professor Wang Kungen’s treatment of gastric precancerous lesions are Chinese thorowax root,turmeric root tuber,pinellia tuber,dried tangerine peel,indian bread,dandelion,and golden thread.The main therapeutic principle is to soothe liver and clear heat,regulate qi and stomach,and remove dampness and phlegm.

关 键 词：胃癌前病变 王坤根 中医传承辅助平台 数据挖掘 

分 类 号：R735.2[医药卫生—肿瘤]