Berberine regulates UCP1 expression by reshaping theconformation of quadruplex formed by the element of theUCP1 gene promoter  

作　　者：Qiuhui Wang Xingke Xu Xiaoqing Jiang Fei Yin 

机构地区：[1]Chongqing Key Laboratory of Medicinal Chemistry&Molecular Pharmacology,Chongqing University of Technology,Chongqing 400054,China [2]College of Pharmacy and Bioengineering,Chongqing University of Technology,Chongqing 400054,China

出　　处：《Acta Biochimica et Biophysica Sinica》2022年第11期1757-1760,共4页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grant from the Scientific and Technological Research Program of Chongqing Municipal Education Commission(No.KJZD-K202101102).

摘　　要：Obesity has become a serious issue due to its worldwide prevalence and is the leading risk factor for other metabolic diseases.Increasing evidence indicates that the activation and recruitment of brown adipose tissue(BAT)and the induction of the expression of uncoupling protein 1(UCP1)are attractive strategies to increase metabolic efficiency and counteract weight gain[1].UCP1,a thermogenic protein,is located in the inner mitochondrial membrane,is mainly expressed in brown and beige/brite adipose tissues and plays critical roles in metabolic and energy balance by releasing chemical energy as heat[2].

关 键 词：UCP1 BERBERINE RELEASING 

分 类 号：R96[医药卫生—药理学]