Synergistic sulfonamides plus clindamycin as an alternative therapeutic regimen for HIV-associated Toxoplasma encephalitis: a randomized controlled trial  

作　　者：Yao Li Yanming Zeng Yanqiu Lu Xuejiao He Yushan Wu Wei Zhang Yanqun Huang Hui Chen Yaokai Chen 

机构地区：[1]Department of Infectious Diseases,Chongqing Public Health Medical Center,Chongqing 400036,China [2]School of Biomedical Engineering,Center for Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China

出　　处：《Chinese Medical Journal》2022年第22期2718-2724,共7页中华医学杂志（英文版）

基　　金：National Science and Technology Major Project of China during the 13th Five-year Plan Period(No. 2018ZX10302104);Key Project of Joint Medical Research Project of Science and Health in Chongqing in 2019(No. 2019ZDXM012);Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Municipal Science and Technology Bureau(No. 2020GDRC004);Chongqing Talent Cultivation Program(No. cstc2021ycjh-bgzxm0275)。

摘　　要：Background: The preferred therapeutic regimen for Toxoplasma encephalitis (TE) is a combination of pyrimethamine and sulfadiazine, and trimethoprim-sulfamethoxazole (TMP-SMX) plus azithromycin is the widespread alternative therapeutic regimen. The synergistic sulfonamides tablet contains TMP, sulfadiazine, and SMX and hypothetically could be used for TE treatment. This study aimed to compare the efficacy and safety of synergistic sulfonamides plus clindamycin (regimen B) with TMP-SMX plus azithromycin (regimen A) for the treatment of human immunodeficiency virus (HIV) associated TE.Methods: This was an open-labeled, multi-center randomized controlled trial recruited from 11 centers. Each recruited patient was randomly assigned to receive regimen A or regimen B for at least 6 weeks. The overall response was evaluated by assessment of the clinical response of TE-associated clinical features and the radiological response of TE-associated radiological findings. The overall response rate, clinical response rate, radiological response rate, and adverse events were assessed at 2, 6, and 12 weeks. Death events were compared between the two regimens at 6, 12, and 24 weeks.Results: A total of 91 acquired immunodeficiency syndrome (AIDS)/TE patients were included in the final analysis (44 in regimen Avs. 47 in regimen B). The overall response rate, which refers to the combined clinical and radiological response, was 18.2% (8/44) for regimen A and 21.3 % (10/47) for regimen B at week 6. The results of clinical response showed that, in comparison with regimen A, regimen B may perform better with regards to its effect on the relief of clinical manifestations (50.0% [22/44]vs. 70.2% [33/47],P = 0.049). However, no significant differences in radiological response, mortality events, and adverse events were found between the two regimens at week 6.Conclusions: Synergistic sulfonamides plus clindamycin, as a novel treatment regimen, showed no significantly different efficacy and comparable safety in comparison with the TMP-SMX plus

关 键 词：CLINDAMYCIN EFFICACY Human immunodeficiency virus/acquired immunodeficiency syndrome Safety Synergistic sulfonamides Toxoplasma encephalitis 

分 类 号：R512.91[医药卫生—内科学] R531.8[医药卫生—临床医学]