Immunomodulatory hybrid bio-nanovesicle for self-promoted photodynamic therapy  

作　　者：Houli Liu Yao Lei Weidong Nie Helin Zhao Yuzhu Wu Liping Zuo Guanghao Wu Ruili Yang Hai-Yan Xie 

机构地区：[1]School of Life Science,Beijing Institute of Technology,Beijing 100081,China [2]School of Materials Science and Engineering,Beijing Institute of Technology,Beijing 100081,China [3]School of Stomatology,Perking University,Beijing 100081,China

出　　处：《Nano Research》2022年第5期4233-4242,共10页纳米研究（英文版）

基　　金：This work was funded by the National Natural Science Foundation of China(Nos.21874011,91859123,and 32101140);the National Science Fund for Distinguished Young Scholars(No.22025401);the China Postdoctoral Science Foundation(No.2020M680396);China Postdoctoral Science Foundation(Nos.2021TQ0037 and 2021M690405);The National Natural Science Foundation of China(No.21904012)。

摘　　要：Thylakoid(Tk)membranes are of unique superiority in photodynamic therapy(PDT)because they not only carry abundant chlorophylls containing photosensitizer porphyrin but also can produce O_(2).However,the current therapeutic performance of Tk is dramatically limited because of their poor tumor targeting and inefficient O_(2) production.Here,we report an immunomodulatory bio-nanovesicle of Tk membranes fused with M1 macrophage-derived extracellular vesicles(M1 EV)for efficient PDT of tumors.The hybrid nanovesicle Tk@M1 was prepared by squeezing the Tk membranes of spinach with M1 EV.The systemic study confirmed that Tk@M1 can not only actively accumulate in tumors but also effectively regulate the inactive immune microenvironment of tumors.Such activated"hot"tumors significantly enhance the PDT efficacy of Tk@M1 attributed to the increased O_(2) from catalase catalyzed decomposition of augmented H_(2)O_(2),providing a novel idea about constructing natural systems for effective tumor treatment.

关 键 词：THYLAKOID photodynamic therapy extracellular vesicle M1 macrophage IMMUNOMODULATION 

分 类 号：TB383[一般工业技术—材料科学与工程]