641份具有磺酰胺结构的非抗菌药物说明书中交叉过敏警示标志分析及处方审核建议  

Analysis of cross allergy warning signs in 641 instructions for non-antibacterial drugs with sulfonamide structure and prescription audit suggestions

作　　者：刘璇 袁龙 李为 刘宇[1] Xuan LIU;Long YUAN;Wei LI;Yu LIU(Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《药物流行病学杂志》2023年第1期25-29,共5页Chinese Journal of Pharmacoepidemiology

摘　　要：目的搜集临床常用具有磺酰胺结构非抗菌药物的药品说明书,分析该类药物说明书中交叉过敏事项的标记情况,探索处方审核策略。方法于2021年12月通过查询药智网说明书数据库、用药助手软件(手机版)以及MCDEX软件(网络版)收集国内常用具有磺酰胺结构非抗菌药物的药品说明书,对说明书中涉及交叉过敏的警示语以及禁忌等内容进行分类汇总分析。结果符合入排标准的药物共分5大类17种药品。共收集641份具有磺酰胺结构非抗菌药物的说明书,包括循环利尿药115份,噻嗪类及相关利尿药189份,磺酰脲类降糖药273份,碳酸酐酶抑制药6份。其中有8种药品的说明书对交叉过敏事项标注存在分歧。结论目前国内具有磺胺结构非抗菌药物的说明书对交叉过敏事项的标注存在分歧,反映出该类药物的交叉过敏在实际应用中还有争议。在制定审方策略时应管控好说明书中的分歧,根据对应说明书的描述实现对此类药品交叉过敏的精准识别与提醒。Objective By collecting the instructions of commonly used clinical sulfonamides non-antibacterial drugs,the labeling of cross-allergic items in the instructions of such drugs was analyzed,and the appropriate prescription review strategy was explored.Methods In December 2021,by querying Yaozhi.com’s instruction manual database,medication assistant software(mobile version)and MCDEX software(online version),we collected the instructions for non-antibacterial drugs with sulfonamide structure commonly used in China,and the instructions for cross-allergic warnings and Taboo content was summarized and analyzed by Excel.Results There were 17 drugs in 5 categories and 641 non-antibacterial drug instructions with sulfonamide structure,including 115 circulating diuretics,189 thiazides and related diuretics,and 273 sulfonylurea antibacterial drugs,6 carbonic anhydrase inhibitors.Among them,the instructions of 8 drugs differed on the labeling of cross allergy.Conclusion At present domestic sulfanilamide structure of antimicrobial manual allergic to cross item tagging is larger differences,which reflects the cross of the drug allergy still exists in the practical application of the larger controversy.In the process of formulating the auditor’s strategy,the differences in the explanation should be well controlled,according to the description of the corresponding instructions,we can accurately identify and remind the cross allergy of such drugs.

关 键 词：磺酰胺结构 非抗菌药物 交叉过敏 药品说明书 药品风险管理 

分 类 号：R95[医药卫生—药学]