靶向转位蛋白正电子示踪剂在神经炎症显像方面的应用  

The application of targeted translocator protein positron tracers in neuroinflammation imaging

作　　者：王明贞 韩巍[1] 付鹏[1] 赵长久[1] Wang Mingzhen;Han Wei;Fu Peng;Zhao Changjiu(Department of Nuclear Medicine,the First Clinical Hospital Affiliated to Harbin Medical University,Harbin 150007,China)

机构地区：[1]哈尔滨医科大学附属第一医院核医学科,哈尔滨150007

出　　处：《国际放射医学核医学杂志》2022年第12期742-748,共7页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：神经炎症是许多中枢神经系统疾病共有的病理表现,而小胶质细胞会在中枢神经系统受到损伤后率先产生应答。相对分子质量为18000的转位蛋白(TSPO)在神经炎症发生时高表达于小胶质细胞,这一特性使得该蛋白适用于评估脑内小胶质细胞的活化增生情况。从靶向TSPO放射性配体研发至今,已有60多种靶向TSPO的放射性配体被研发用于神经炎症疾病的研究,以期对其病理过程有更深入的了解。笔者就靶向TSPO正电子示踪剂在神经炎症显像方面的应用进行综述。Neuroinflammation is a common pathological manifestation of many central nervous system diseases,and microglia are the first to respond to damage to the central nervous system.The relative molecular mass of 18000 translocator protein(TSPO)is highly expressed in microglia at the onset of neuroinflammation,a property that makes it suitable for assessing the activation of microglia proliferation in the brain.Since the development of radioligands targeting TSPO,more than 60 radioligands targeting TSPO have been developed for the study of neuroinflammatory diseases in order to gain a better understanding of their pathological processes.The author reviews the use of targeted TSPO positron tracers for neuroinflammatory imaging.

关 键 词：神经炎 正电子发射断层显像术 小胶质细胞 转位蛋白 TSPO放射性配体 

分 类 号：R741[医药卫生—神经病学与精神病学]